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Background: Psittacosis is a zoonotic disease with a low incidence rate and a lack of specificity in clinical manifestations, making it prone to be missed, misdiagnosed, and even cause delayed treatment for patients. Metagenomic next-generation sequencing (mNGS) was successfully performed for the diagnosis of a young patient with psittacosis progressing to acute respiratory distress syndrome (ARDS), and precisely targeted antibiotic treatment was promptly administered. Additionally, a comprehensive review was conducted on 68 cases of psittacosis complicated with ARDS, with the goal of improving the clinical awareness of this disease.

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Psittacosis Pneumonia Features, Distinguishing Characteristics, and Outcomes: A Retrospective Study.

Infect Drug Resist

December 2024

Department of Infectious Diseases, Shaoxing People's Hospital, Shaoxing, Zhejiang, People's Republic of China.

Purpose: Psittacosis is an often-neglected cause of community acquired pneumonia (CAP). The limited diagnostic methods for psittacosis pneumonia invariably result in an unfavourable prognosis. Consequently, the early detection of psittacosis pneumonia is crucial.

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Background: Psittacosis is a zoonotic infectious disease caused by () infection, which can be transmitted by birds, poultry and wild animals. The symptoms and imaging findings of pneumonia are atypical and primarily rely on etiological diagnosis. The incidence of infection has been significantly underestimated because of the low sensitivity and poor timeliness of traditional diagnostic methods.

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Objectives: Detection and diagnosis of () pneumonia is often overlooked due to conventional methods limitations and similarity to other atypical community acquired pneumonia (CAP). Using mNGS, we aimed to distinguish psittacosis from legionellosis for early pneumonia diagnosis and better prognosis.

Methods: Thirty-seven patients diagnosed with atypical CAP were enrolled in this retrospective study, including 14  pneumonia and 23 () pneumonia.

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Comparison of clinical, laboratory and radiological characteristics between COVID-19 and Chlamydia psittaci pneumonia: a multicenter retrospective study.

Sci Rep

October 2024

Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, 410008, China.

Article Synopsis
  • - The study compares Chlamydia psittaci pneumonia (CPP) and COVID-19, revealing that both share similar outbreak patterns and symptoms but have distinct clinical manifestations.
  • - Key differences include a higher incidence of nervous system symptoms and worse inflammatory indicators in CPP patients, along with a tougher prognosis reflected in higher mortality and severe pneumonia rates.
  • - A nomogram was developed based on five risk factors—nervous system symptoms, lymphocytes, creatine kinase levels, bilateral lung lesions, and ground-glass opacity—to effectively distinguish CPP from COVID-19, achieving a high concordance index of 0.989.
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