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Kaposi Varicelliform Eruption in a Chronic Kidney Disease Individual Under Tacrolimus: A Case Report.
Case Rep Dermatol Med
October 2024
Department of Dermatology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
"Kaposi varicelliform eruption" (KVE), also known as "eczema herpeticum," refers to a rare widespread skin infection. The primary causal agent is thought to be the herpes simplex virus (HSV). Though common in patients with underlying skin dermatosis, systemic immunosuppression can at times lead to KVE.
View Article and Find Full Text PDFSevere herpes simplex virus - 1 Kaposi varicelliform eruption and SARS-CoV-2 infection in atopic dermatitis treated with dupilumab.
BMC Infect Dis
November 2024
Department of Dermatology, The First Affiliated Hospital of Chongqing College of Traditional Chinese Medicine, No. 40 Daomenkou St., District Yuzhong, Chongqing, 400011, P.R. China.
Article Synopsis
- A case report discusses a 35-year-old male with a history of atopic dermatitis who developed a severe herpes simplex virus-1 (HSV-1) related skin condition called Kaposi varicelliform eruption (KVE) after a recent SARS-CoV-2 infection.
- The patient's skin condition involved widespread vesicles and pustules that rapidly progressed over four months, and laboratory tests confirmed he was positive for HSV-1 with elevated IgE levels and decreased immune cell counts.
- Treatment with valaciclovir and other medications led to significant improvement, with the skin lesions resolving completely within a week, emphasizing the risk of severe viral eruptions in patients with existing skin conditions following viral infections.
[Erythroderma Complicated With Kaposi Varicelliform Eruption:Report of One Case].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
October 2024
Department of Dermatology, Second Hospital of Shanxi Medical University,Taiyuan 030001,China.
Kaposi varicelliform eruption (KVE) refers to an infectious skin disease that occurs after infection with herpes simplex virus,Coxsackie virus,or other viruses on the basis of preexisting skin diseases,commonly observed in the patients with eczema.It is rare for the patients with erythroderma to be complicated with KVE,and symptoms are often atypical,which pose a challenge to the diagnosis and treatment.This article reports a case of erythroderma complicated with KVE,aiming to raise awareness of clinicians in treating this disease.
View Article and Find Full Text PDFEczema Herpeticum: Clinical Insights and Pathogenesis Hypotheses on Basolateral Adhesion Proteins.
Cureus
August 2024
Internal Medicine, XXI Century National Medical Center, Ciudad de México, MEX.
Article Synopsis
- Eczema herpeticum (EH) is a serious viral infection caused by the herpes simplex virus that affects individuals with fragile skin, particularly those with atopic dermatitis (AD), leading to severe skin lesions and possible systemic issues.
- A case report describes an EH diagnosis in a five-year-old girl with AD, characterized by fever and painful skin lesions, ultimately confirmed through positive IgM anti-HSV-1 serology despite initial lack of confirmatory tests.
- The girl was treated with intravenous aciclovir and showed significant improvement in just 48 hours, emphasizing the need for quick diagnosis and treatment, as well as further research on the link between structural protein changes and immune dysfunction in EH.
Short-form thymic stromal lymphopoietin (sfTSLP) restricts herpes simplex virus infection of human primary keratinocytes.
J Med Virol
September 2024
Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Article Synopsis
- Eczema herpeticum (EH) is a severe herpes simplex virus type 1 (HSV-1) infection that commonly affects individuals with atopic dermatitis (AD) and is influenced by genetic, environmental, and immunological factors.
- The study focuses on thymic stromal lymphopoietin (TSLP), which has two forms: a long form primarily linked to type 2 immune responses, and a short form (sfTSLP) known for its anti-inflammatory and antimicrobial effects.
- Results indicate that sfTSLP effectively reduces HSV-1 infection in human primary keratinocytes by lowering virus gene expression and replication, demonstrating significant antiviral properties without needing new protein synthesis.
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