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[Acute flaccid paralysis surveillance in Niger from 1998 to 2021].
Med Trop Sante Int
December 2024
Département de médecine et spécialités médicales, Université Abdou Moumouni, FSS, Hôpital général de référence, BP 10896, Niamey, Niger.
Introduction: Acute flaccid paralysis (AFP) caused by acute anterior poliomyelitis (AAP) remains endemic in some Asian and African countries, particularly Niger. Performance indicators defined by the WHO are used to evaluate the AFP surveillance system in affected countries. The objective of this study is to assess its outcomes in Niger from 1998 to 2021.
View Article and Find Full Text PDF[Immunisation under conditions of scarcity-the standard and practice of vaccination in the German Democratic Republic from 1949 to 1970].
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
March 2025
Institut für Geschichte der Medizin, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Deutschland.
In the German Democratic Republic (GDR), a tightly organised vaccination system was established in the 1950s and 1960s. In this context, the medical effort to stop the spread of infectious diseases in the post-war period was coupled with the political will to present itself as a responsible preventive state. Based on unpublished archival material, we will shed light on the everyday practice of vaccination in the early GDR.
View Article and Find Full Text PDFGlobal withdrawal of Sabin oral poliovirus type 2 vaccine in 2016.
Science
March 2025
SESB members and their affiliations are listed at the end of this article.
Evaluation guides strategy for the polio eradication endgame.
View Article and Find Full Text PDFA novel de novo GFAP variant causes a juvenile-onset Alexander disease with bilateral vocal cord paralysis.
Gene
March 2025
Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy.
Alexander disease (AxD), an autosomal dominant leukodystrophy, is caused by mutations in the GFAP, the gene encoding glial fibrillary acidic protein (GFAP). The disease, classified by age of onset into infantile, juvenile, and adult forms, is characterized by white matter degeneration and astrocytic inclusions called Rosenthal fibers. A patient underwent clinical, radiological, and molecular analyses to confirm a suspected diagnosis of AxD.
View Article and Find Full Text PDFSevere coxsackie virus B5 encephalitis mimics autoimmune limbic encephalitis in a young woman under long-term B-cell depletion with ocrelizumab: A case report.
Mult Scler
February 2025
Department of Neurology, Saarland University Medical Center, Saarland University, Homburg, Germany.
Background: B-cell-depleting therapies are increasingly being used to treat autoimmune diseases. Although thousands of patients are and have been treated with these agents, the data are not yet strong enough to identify rare side effects with certainty.
Methods: We report the case of a patient undergoing ocrelizumab therapy for relapsing multiple sclerosis who developed a severe limbic syndrome.
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