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Biomarkers.
Alzheimers Dement
December 2024
Department of Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Background: Hippocampal atrophy is an established biomarker of neurodegeneration in Alzheimer's disease, affecting specific subfields (De Flores, La Joie and Chételat, 2015). In this study, we used 7T MRI and advanced diffusion MRI (dMRI) to investigate the relationship between hippocampal subfield volumes and microstructure and assess their sensitivity to cognitive impairment.
Method: Seventeen cognitively impaired (CI; age: 69±8, M/F: 12/5, MMSE: 28) and 22 cognitively unimpaired subjects (CU; age: 62±10, M/F: 6/16) were recruited in the context of the COSCODE project (Ribaldi et al.
Tricuspid valve edge-to-edge repair simulations are highly sensitive to annular boundary conditions.
J Mech Behav Biomed Mater
December 2024
Department of Mechanical Engineering, The University of Texas at Austin, 204 E. Dean Keeton Street, Austin, TX, 78712, USA; Department of Aerospace Engineering & Engineering Mechanics, The University of Texas at Austin, 2617 Wichita Street, Austin, TX, 78712, USA; Department of Biomedical Engineering, The University of Texas at Austin, 107 W. Dean Keeton Street, Austin, TX, 78712, USA; The Oden Institute for Computational Engineering & Sciences, The University of Texas at Austin, 201 E. 24th Street, Austin, TX, 78712, USA. Electronic address:
Transcatheter edge-to-edge repair (TEER) simulations may provide insight into this novel therapeutic technology and help optimize its use. However, because of the relatively short history and technical complexity of TEER simulations, important questions remain unanswered. For example, there is no consensus on how to handle the annular boundary conditions in these simulations.
View Article and Find Full Text PDFScientific and Clinical Impacts of UK Biobank in Cardiovascular Medicine.
Circulation
December 2024
Nuffield Department of Population Health, University of Oxford, UK (A.J.L., R.C.).
Design of an intelligent wearable device for real-time cattle health monitoring.
Front Robot AI
November 2024
Dyson School of Design Engineering, Imperial College London, London, United Kingdom.
In the realm of precision cattle health monitoring, this paper introduces the development and evaluation of a novel wearable continuous health monitoring device designed for cattle. The device integrates a sustainable solar-powered module, real-time signal acquisition and processing, and a storage module within an animal ergonomically designed curved casing for non-invasive cattle health monitoring. The curvature of the casing is tailored to better fit the contours of the cattle's neck, significantly enhancing signal accuracy, particularly in temperature signal acquisition.
View Article and Find Full Text PDFAssociation between Accelerometer-Measured Irregular Sleep Duration and Longitudinal Changes in Body Mass Index in Older Adults.
medRxiv
November 2024
Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.
Irregular sleep duration may disrupt circadian rhythms and contribute to metabolic, behavioral, and mood changes, potentially increasing the risk for obesity. However, quantitative data on the relationship between sleep duration irregularity and weight change are lacking. In this prospective study, we analyzed data from 10,572 participants (mean age: 63 years) in the UK Biobank who wore accelerometers for a week between 2013-2015 and had two body mass index (BMI; kg/m) measurements on average 2.
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