Interaction of carbenicillin with kanamycin, gentamicin, tobramycin, and amikacin, as well as that of cefotaxime with the same aminoglycosides were studied. It was shown that carbenicillin inactivated aminoglycosides in a patient's plasma, urine, rH 5.3-8.44, and in buffer solutions, pH 3.7, 7.5 and 9.25. The inactivation level was the least in acid media. The mechanism of the inactivation was elucidated: opening of the carbenicillin beta-lactam ring occurred at the start.
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