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Preclinical and in silico studies of 3-benzothioyl-1-(3-hydroxy-3-phenyl-3-propyl)-1-methylthiourea: A promising agent for depression and anxiety.
Eur J Pharmacol
February 2025
Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan; Department of Pharmacy, Korea University, Sejong, 20019, South Korea. Electronic address:
The study investigated the anxiolytic, antidepressant, sedative/hypnotic and in silico molecular docking properties of the synthetic ephedrine-based derivative of thiourea, 3-benzothioyl-1-(3-hydroxy-3-phenyl-3-propyl)-1-methylthiourea. Safety profile of the compound at various doses was determined in an acute toxicity test. Results showed significant anti-anxiety effects of the compound in all mice studies.
View Article and Find Full Text PDFSedation Practices in Mechanically Ventilated Neurocritical Care Patients from 19 Countries: An International Cohort Study.
Neurocrit Care
January 2025
Division of Neuroscience Critical Care, Departments of Neurology, Neurosurgery, and Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Our objective was to characterize the impact of common initial sedation practices on invasive mechanical ventilation (IMV) duration and in-hospital outcomes in patients with acute brain injury (ABI) and to elucidate variations in practices between high-income and middle-income countries.
Methods: This was a post hoc analysis of a prospective observational data registry of neurocritically ill patients requiring IMV. The setting included 73 intensive care units (ICUs) in 18 countries, with a total of 1,450 patients with ABI requiring IMV.
Objective: Aim: Using morphometric methods to study the features of endotheliocyte remodeling of the arterial and venous beds of the testicles during long-term ethanol intoxication.
Patients And Methods: Materials and Methods: Endotheliocytes of the arterial and venous bed of the left and right testes of 60 white male rats, which were divided into two groups, were morphologically studied. The 1 group consisted of 30 intact animals, the 2 - 30 rats, which were daily intragastrically injected with a 30 % ethanol solution at the rate of 2 ml per 100 g of the animal's weight for 28 days.
The effect of cell therapy on the intensity of lipid peroxidation processes in the liver, kidneys and lungs of rats of different ages under conditions of experimental cranio-skeletal trauma.
Wiad Lek
December 2024
I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, MINISTRY OF HEALTH OF UKRAINE, TERNOPIL, UKRAINE.
Objective: Aim: To determine the effect of cell therapy on the intensity of lipid peroxidation processes in the liver, kidneys and lungs of rats of different ages under conditions of experimental cranio-skeletal trauma (CST).
Patients And Methods: Materials and Methods: In the experiments, 129 white male Wistar line rats of different age groups were used: immature rats aged 100-120 days and weighing 90-110 g; mature rats aged 6-8 months and weighing 180-200 g; and old rats aged 19-23 months and weighing 300-320 g. In each age group, CST was modeled under thiopental sodium anesthesia.
Comparing the Effects of Propofol and Thiopental on Human Renal HEK-293 Cells With a Focus on Reactive Oxygen Species (ROS) Production, Cytotoxicity, and Apoptosis: Insights Into Dose-Dependent Toxicity.
Cureus
November 2024
Medical Biochemistry, Harran University, Şanliurfa, TUR.
Objectives: Propofol and thiopental are widely used as hypnotic, sedative, antiepileptic, and analgesic agents in general anesthesia and intensive care; however, their side effects remain unknown. They are used for long periods and at high doses for sedation in total intravenous anesthesia (TIVA) and intensive care units. Long-term and high-dose use of these drugs can lead to accumulation in plasma and tissues, resulting in high drug concentrations and increasing the risk of potential toxicity (e.
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