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Quercetin inhibits platelet activation and ER-stress mediated autophagy in response to extracellular histone.
Phytomedicine
January 2025
Department of Studies and Research in Biochemistry, Tumkur University, Tumakuru 572103, India. Electronic address:
Background: Cellular histones are DNA-binding nuclear proteins involved in chromatin remodelling and regulation of gene expression. However, extracellular histones act as damage-associated molecular patterns (DAMPs) and contribute to multiorgan damage in conditions with sepsis and diseases with acute critical illnesses. Alongside, histones are associated with thrombocytopenia due to dysfunctional platelets that regulate hemostasis and thrombosis.
View Article and Find Full Text PDFThe natural flavonoid pinocembrin shows antithrombotic activity and suppresses septic thrombosis.
Int Immunopharmacol
December 2024
Division of Cardiology, State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:
Sepsis, an extreme host response to systemic infection, remains one of the leading causes of mortality worldwide. Platelets, which are integral to both thrombosis and inflammation, play a crucial role in the pathophysiology of sepsis. Excessive platelet activation and aggregation significantly increase the risk of thrombosis, thereby elevating mortality in septic patients.
View Article and Find Full Text PDFChronic Epinephrine-Induced Endoplasmic Reticulum and Oxidative Stress Impairs Pancreatic β-Cells Function and Fate.
Int J Mol Sci
June 2024
College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
Article Synopsis
- Epinephrine affects pancreatic β-cells mainly through the α2A-adrenergic receptor, temporarily reducing insulin secretion but eventually causing increased insulin release with prolonged exposure.
- A study on MIN6 cells revealed that chronic epinephrine treatment results in α2A-AR desensitization, enhanced insulin secretion, and problems with insulin granule docking and Syntaxin-2.
- Analysis showed chronic exposure to epinephrine causes cell cycle inhibition and stress in the endoplasmic reticulum and mitochondria, leading to negative changes in β-cell function and survival.
Role of Phenylethanolamine-N-methyltransferase on Nicotine-Induced Vasodilation in Rat Cerebral Arteries.
Microcirculation
July 2024
Division of Urology, Department of Surgery, Taipei Tzu Chi Hospital, New Taipei, Taiwan.
Objective: The sympathetic-parasympathetic (or axo-axonal) interaction mechanism mediated that neurogenic relaxation, which was dependent on norepinephrine (NE) releases from sympathetic nerve terminal and acts on β-adrenoceptor of parasympathetic nerve terminal, has been reported. As NE is a weak β-adrenoceptor agonist, there is a possibility that synaptic NE is converted to epinephrine by phenylethanolamine-N-methyltransferase (PNMT) and then acts on the β-adrenoceptors to induce neurogenic vasodilation.
Methods: Blood vessel myography technique was used to measure relaxation and contraction responses of isolated basilar arterial rings of rats.
Stress-induced epinephrine promotes hepatocellular carcinoma progression via the USP10-PLAGL2 signaling loop.
Exp Mol Med
May 2024
Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, PR China.
Hepatocellular carcinoma (HCC) is associated with a poor prognosis. Our previous study demonstrated that Pleomorphic adenoma gene like-2 (PLAGL2) was a potential therapeutic target in HCC. However, the mechanisms that lead to the upregulation of PLAGL2 in HCC remain unclear.
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