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| http://dx.doi.org/10.1136/bmj.1.4500.468 | DOI Listing |
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Placental Hypoxia-Induced Ferroptosis Drives Vascular Damage in Preeclampsia.
Circ Res
January 2025
Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada (C.P., S.A., J.W.A., R.L., F.N., J.S., I.C.).
Background: Iron is an essential micronutrient for cell survival and growth; however, excess of this metal drives ferroptosis. Although maternal iron imbalance and placental hypoxia are independent contributors to the pathogenesis of preeclampsia, a hypertensive disorder of pregnancy, the mechanisms by which their interaction impinge on maternal and placental health remain elusive.
Methods: We used placentae from normotensive and preeclampsia pregnancy cohorts, human H9 embryonic stem cells differentiated into cytotrophoblast-like cells, and placenta-specific preeclamptic mice.
Long-term results of lymphedema treatment with Combined lymph node transfer and collagen scaffolds: An Observational Study.
JPRAS Open
March 2025
Department of Plastic Surgery, Aristotle University of Thessaloniki, School of Medicine, Papageorgiou General Hospital, Thessaloniki, 54603, Greece.
Aim: Vascularized lymph node transfer (VLNT) accelerates growth factor secretion, lymphatic endothelial cell migration toward the interstitial flow and lymphagiogenesis in a multidirectional pattern. Our observational study aimed to examine the hypothesis that nanofibrillar collagen scaffolds (NCS) combined with VLNT can provide guided lymphagiogenesis creating long-lasting lymphatic pathways.
Methods: Twenty-four patients (21 female, 3 male) underwent a lymphatic microsurgery for upper ( = 11) or lower ( = 13) limb secondary lymphedema and completed at least 18 months follow-up were selected and equally divided in 2 groups; Group-A underwent VLNT, Group-B underwent combined VLNT and NCS procedure.
Preoperative waiting time and outcomes of non-traumatic emergency abdominal surgeries: Insights from a zonal referral hospital in northern Tanzania, a reference for health centers with similar capacities.
Surg Pract Sci
September 2023
Department of Surgery, Kilimanjaro Christain Medical University College, Kilimanjaro, Moshi, Tanzania.
Background: Non-traumatic emergency abdominal surgeries are common in most healthcare settings. To a significant extent, the outcomes of treatment are determined by the promptness of surgical interventions. However, the in-hospital waiting time which reflects perioperative promptness remains largely unexplored in developing countries.
View Article and Find Full Text PDFLymph node yield as a measure of pancreatic cancer surgery quality.
Surg Pract Sci
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Geisinger Medical Center, 100 N. Academy Ave., Danville, PA 17822, United States.
Introduction: Evaluated lymph node (ELN) yield has been established as a promising measure of surgical quality. Research has suggested that an ELN of at least 15 in pancreatic cancer patients is associated with improved survival and staging metrics. The aim of this study was to determine what impact a high ELN yield of ≥15 has in a novel population.
View Article and Find Full Text PDFEndovascular repair versus surgery for mycotic aneurysm a retrospective study with Bayesian inference.
Surg Pract Sci
September 2022
Department of Research Support, Center for Clinical Research and Innovation, Kobe City Medical Center, General Hospital, Japan.
Introduction: Because mycotic aneurysm is a rare infection, the effectiveness of endovascular aneurysm repair (EVAR) and thoracic endovascular aortic repair (TEVAR) for mycotic aneurysm is difficult to evaluate.
Methods: We conducted a retrospective cohort study comparing EVAR/TEVAR and surgical repair (SR), using both Cox proportional regression analysis and Bayesian inference for patients with mycotic aneurysm diagnosed between January 2008 and December 2015.
Results: A total of 38 patients with mycotic aneurysm were included in the study.
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