The study aimed to examine the tolerability of the combination of radiotherapy and tamoxifen and the effect on median and event free survival as well as collecting data on the use of steroids in this population. 31 patients with diffuse intrinsic pontine glioma, diagnosed on clinical and radiological criteria, were treated with high-dose oral tamoxifen (120 mg/m(2)/day) given concomitantly with standard dose radiotherapy (54 Gy in 1.8 Gy fractions over 6 weeks). Results Tamoxifen was well tolerated with no grade 3 or 4 CTC toxicity reported. At 1 year, the progression free and event free survival were 3.2% (95% CI: 0.2-14.1%), and at 6 months 19.4% (CI: 7.9% to 34.6%). The overall survival at 1 year was 16.1% (CI: 5.9-30.9%) with median survival 6.32 months. In this study, in which tamoxifen was used in conjunction with radiotherapy, progression free survival was shown to be less good when compared with historical data HR = 3.1 (CI: 1.7-5.7). There was no significant reduction in overall survival. The addition of high-dose tamoxifen, although well tolerated, confers no clinical benefit to patients treated with diffuse intrinsic pontine glioma treated with standard radiotherapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11060-010-0141-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Design and synthesis of autogenous growth NiFe bimetallic phosphide catalysts on a nickel iron foam-like substrate for efficient overall water splitting.
J Colloid Interface Sci
January 2025
Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province, School of Resources and Materials, Northeastern University at Qinhuangdao, Qinhuangdao 066004, PR China. Electronic address:
Article Synopsis
- The study focuses on creating effective and affordable electrocatalysts for water electrolysis, vital for improving technology in this area.
- The authors developed a novel catalyst by anchoring carbonyl iron powder in nickel foam, leading to enhanced surface area and efficient ion movement.
- The catalyst exhibits high activity due to a dynamic interaction between different nickel and iron phases, significantly boosting its performance in the oxygen evolution reaction.
Evidence for intrinsic DNA dynamics and deformability in damage sensing by the Rad4/XPC nucleotide excision repair complex.
Nucleic Acids Res
January 2025
Department of Physics, 845 W Taylor St, University of Illinois Chicago, Chicago, IL 60607, USA.
Altered DNA dynamics at lesion sites are implicated in how DNA repair proteins sense damage within genomic DNA. Using laser temperature-jump (T-jump) spectroscopy combined with cytosine-analog Förster Resonance Energy Transfer (FRET) probes that sense local DNA conformations, we measured the intrinsic dynamics of DNA containing 3 base-pair mismatches recognized in vitro by Rad4 (yeast ortholog of XPC). Rad4/XPC recognizes diverse lesions from environmental mutagens and initiates nucleotide excision repair.
View Article and Find Full Text PDFEffect of rPET Content and Preform Heating/Cooling Conditions in the Stretch Blow Molding Process on Microcavitation and Solid-State Post-Condensation of vPET-rPET Blend: Part II-Statistical Analysis and Interpretation of Tests.
Materials (Basel)
December 2024
Faculty of Physics and Astronomy, University of Wroclaw, 9 Maxa Born Square, 50-204 Wroclaw, Poland.
This research explores how varying proportions of virgin polyethylene terephthalate (vPET) and recycled polyethylene terephthalate (rPET) in vPET-rPET blends, combined with preform thermal conditions during the stretch blow molding (SBM) process, influence PET bottles' microscopic characteristics. Key metrics such as viscosity, density, crystallinity, amorphous phase relaxation, and microcavitation were assessed using response surface methodology (RSM). Statistical analysis, including Analysis of variance (ANOVA) and its power, supported the interpretation of results.
View Article and Find Full Text PDFPolymer Solutions in Microflows: Tracking and Control over Size Distribution.
Polymers (Basel)
December 2024
Department of Physical and Colloid Chemistry, Kazan National Research Technological University, 420015 Kazan, Russia.
Microfluidics provides cutting-edge technological advancements for the in-channel manipulation and analysis of dissolved macromolecular species. The intrinsic potential of microfluidic devices to control key characteristics of polymer macromolecules such as their size distribution requires unleashing its full capacity. This work proposes a combined approach to analyzing the microscale behavior of polymer solutions and modifying their properties.
View Article and Find Full Text PDFSynergistically Boosted Na Migration and Deep Desodiation Stability of NASICON Cathode via High Entropy Regulation.
Small
January 2025
College of Materials Science and Engineering, Hunan University, Changsha, 410082, China.
Mn-containing sodium superionic conductor (NASICON) compounds have shown considerable potential as cathode for sodium-ion batteries (SIBs) owing to higher working voltage (V/V: 3.9 V), lower cost, and lower toxicity compared to full vanadium-based NASICON NaV(PO). Taking NaVMn(PO) (NVMP) as an example, its practical application is still restricted by poor electronic conductivity, sluggish intrinsic Na diffusion, and poor high-voltage stability.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!