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Solid state NMR spectral editing of histidine, arginine and lysine using Hadamard encoding.
J Biomol NMR
January 2025
Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
The NMR signals from protein sidechains are rich in information about intra- and inter-molecular interactions, but their detection can be complicated due to spectral overlap as well as conformational and hydrogen exchange. In this work, we demonstrate a protocol for multi-dimensional solid-state NMR spectral editing of signals from basic sidechains based on Hadamard matrix encoding. The Hadamard method acquires multi-dimensional experiments in such a way that both the backbone and under-sampled sidechain signals can be decoded for unambiguous editing in the N spectral frequency dimension.
View Article and Find Full Text PDFExploring wood-derived biochar potential for electrochemical sensing of fungicides mancozeb and maneb in environmental water samples.
Talanta
January 2025
Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 3, 21000, Novi Sad, Serbia.
The sustainable material, biochar (BC) from a hardwood source, was synthesized via pyrolysis process at 400 °C (BC400) and 700 °C (BC700) and used as a modifier during the electrochemical sensor design. The prepared BCs were characterized by scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, and elemental analysis (CHNS). The development of rapid analytical techniques for detecting pesticides employing a low-cost carbon paste electrode (CPE) modified with BC is a novel strategy to provide a sensitive response to water pollution.
View Article and Find Full Text PDFBackground Thiopurine metabolites, 6-thioguanine (6TG) and 6-methylmercaptopurine (6MMP), are monitored to aid therapeutic management of thiopurine drugs. At Manchester University NHS Foundation Trust (MFT), thiopurine metabolites are measured by high performance liquid chromatography with ultraviolet detection (HPLC-UV). Whole blood samples are lysed and subjected to hydrolysis with derivatisation of 6MMP before HPLC-UV detection at 304nm for the 6MMP-derivative and 342nm for 6TG.
View Article and Find Full Text PDFMitigating dithiothreitol interference to gold/thiol interface in electrochemical detection of cathepsin B activity toward multiplex protease analysis.
Biosens Bioelectron
January 2025
Department of Chemistry, Kansas State University, Manhattan, KS, 66502, USA. Electronic address:
Proteases are overexpressed at various stages of conditions such as cancers and thus can serve as biomarkers for disease diagnosis. Electrochemical techniques to detect the activity of extracellular proteases have gained attraction due to their multiplexing capability. Here we employ an electrochemical approach based on a 3 × 3 gold (Au) microelectrode array (MEA) functionalized with (2-aminoethyl)ferrocene (AEF) tagged specific peptide substrates to monitor cathepsin B (CB) protease activity.
View Article and Find Full Text PDFLow hysteresis and high sensitivity TPU/carbonized wood cellulose sponge sensors for monitoring dynamic pulses.
Int J Biol Macromol
January 2025
School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China.
The importance of continuous and reliable pulse wave monitoring is constantly being increased in health signal monitoring and disease diagnoses. Flexible pressure sensors with high sensitivity, low hysteresis and fast response time are an effective means for monitoring pulses. Herein, a special wave-shaped layered porous structure of carbonized wood cellulose sponge (CWCS) was constructed based on natural wood (NW).
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