AI Article Synopsis
- The nucleus has a structured 3D organization that influences gene expression by positioning the genome effectively within its space.
- Recent technology has shown that chromatin forms loops to connect distant regulatory elements with the genes they control, a key mechanism for enhancer-promoter communication.
- There are emerging suggestions that regulatory elements might influence genes on different chromosomes, but definitive evidence is still needed, highlighting ongoing debates and gaps in our understanding of gene expression mechanisms.
Article Abstract
The nucleus is an ordered three-dimensional entity, and organization of the genome within the nuclear space might have implications for orchestrating gene expression. Recent technological developments have revealed that chromatin is folded into loops bringing distal regulatory elements into intimate contact with the genes that they regulate. Such intrachromosomal contacts appear to be a general mechanism of enhancer-promoter communication in cis. Tantalizing evidence is emerging that regulatory elements might have the capacity to act in trans to regulate genes on other chromosomes. However, unequivocal data required to prove that interchromosomal gene regulation truly represents another level of control within the nucleus is lacking, and this concept remains highly contentious. Such controversy emphasizes that our current understanding of the mechanisms that govern gene expression are far from complete.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865229 | PMC |
| http://dx.doi.org/10.1016/j.tig.2010.01.007 | DOI Listing |
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