AI Article Synopsis
- The study researched the anti-inflammatory properties and stomach safety of a 70% ethanol extract from Cordia verbenacea leaves using rat and mouse models.
- The extract notably reduced swelling from nystatin and was more effective at decreasing ear swelling compared to naproxen when applied topically.
- At doses that provided anti-inflammatory effects, the extract also protected the stomach lining, significantly lowering the number of gastric lesions.
Article Abstract
The antiinflammatory effects and gastrotoxicity of a lyophilized 70% ethanol extract of the leaves of Cordia verbenacea were investigated through experimental models in rats and mice. The oral administration of 1.24 mg/kg of the extract significantly inhibited nystatin-induced oedema. Topical application of the extract at a dose of 0.09 mg/ear in mice was clearly more effective than 1.0 mg/ear of naproxen in the reduction of the ear oedema induced by corton oil. At antiinflammatory doses, the extract showed an important protective effect on the gastric mucosa, reducing significantly the number of gastric lesions.
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| http://dx.doi.org/10.1016/0378-8741(91)90008-2 | DOI Listing |
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