Proliferative verrucous leukoplakia (PVL) is of uncertain etiology but may be associated with human papillomavirus (HPV) infection. Proliferative verrucous leukoplakia is seen mainly in older women, beginning as a simple slow-growing, persistent leukoplakia that tends to spread and become multifocal and affect the gingival frequently. In time, PVL develops exophytic, wart-like or erythroplakic areas that become squamous carcinomas. Proliferative verrucous leukoplakia appears to resist to all attempts at therapy and often recurs.
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DNA methylation analysis from oral brushing reveals a field cancerization effect in proliferative verrucous leukoplakia.
Pathologica
December 2024
Functional and Molecular Neuroimaging Unit, Bellaria Hospital, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Objectives: The aim of the present study was to analyze the methylation status in patients who presented with an Oral Squamous Cell Carcinoma (OSCC) concomitantly with multifocal Proliferative Verrucous Leukoplakia (PVL)(PVL-OSCC).
Methods: Nine patients with OSCC and concomitant PVL lesions were selected. Two brushing samples were collected simultaneously from OSCC and PVL lesions in contralateral mucosa from each patient.
Bibliometric analysis of 100 most cited papers on oral proliferative verrucous leukoplakia.
J Oral Biol Craniofac Res
December 2024
Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune, 411018, MH, India.
Background: Bibliometric analysis of highly cited papers in a particular discipline brings forward the impactful papers published, the significant journals and the researchers in the field. These studies help in identifying research trends and research lacunae in the field, thus guiding the future research works. Oral proliferative verrucous leukoplakia (OPVL) is a challenging lesion with no uniform diagnostic criteria.
View Article and Find Full Text PDFDemographic and clinicopathological comparison among oral lichen planus, lichenoid lesions and proliferative verrucous leukoplakia: a retrospective study.
BMC Oral Health
December 2024
Dental Sciences Graduate Program. Federal University of Espirito Santo (UFES), Avenida Maruípe 1468, Maruípe, Vitória, 29040-090, ES, Brazil.
Article Synopsis
- The study focused on comparing oral lichen planus and related lesions due to their risk of becoming cancerous and the need to differentiate them from similar conditions.
- Researchers conducted a survey among patients to collect sociodemographic and clinical data, analyzing this information using statistical tests.
- The findings revealed distinct characteristics for each type of lesion, with lichen planus showing reticular patterns and the buccal mucosa being the most affected area, while proliferative verrucous leukoplakia was linked with significant epithelial dysplasia.
Case report: Non-invasive cyto-salivary sampling and biomarker detection via ELISA versus histopathology for diagnosing oral potentially malignant disorders - Insights from a case-control study.
Front Immunol
December 2024
Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.
Oral leukoplakia is classified among oral potentially malignant disorders (OPMDs) by the World Health Organization (WHO). The visual oral examination (VOE) is the most used method for identifying lesions in their early stages. Given that the diagnosis of oral cancer is often late, there is an urgent need for early detection and examination of oral lesions.
View Article and Find Full Text PDFEradication of proliferative verrucous leukoplakia with toll-like receptor 7 agonist (topical imiquimod): a case report.
Front Oncol
November 2024
Department of Otolaryngology-Head & Neck Surgery, Medical University of South Carolina, Charleston, SC, United States.
Proliferative verrucous leukoplakia (PVL) is an aggressive and distinct type of oral precancerous lesion characterized by warty surfaced white plaque diffusely involving oral mucosa. Surgical excision is the treatment of choice. However, PVL has persistent and recurrent growth patterns, requiring multiple surgical procedures.
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