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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480632 | PMC |
| http://dx.doi.org/10.1002/anie.200906153 | DOI Listing |
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Simple amides of oleanolic acid as effective penetration enhancers.
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Department of Organic Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka Str. 6, 60-780 Poznan, Poland.
Transdermal transport is now becoming one of the most convenient and safe pathways for drug delivery. In some cases it is necessary to use skin penetration enhancers in order to allow for the transdermal transport of drugs that are otherwise insufficiently skin-permeable. A series of oleanolic acid amides as potential transdermal penetration enhancers was formed by multistep synthesis and the synthesis of all newly prepared compounds is presented.
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