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Increased severity of multidrug-resistant Shigella sonnei infections in people experiencing homelessness.
Clin Infect Dis
November 2024
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
Background: Shigella sonnei has caused sexually transmitted enteric infections in men who have sex with men (MSM) in Vancouver. We recently observed a high rate of multidrug-resistant (MDR) S. sonnei bacteremia among persons experiencing homelessness (PEH).
View Article and Find Full Text PDFPresence of Pseudomonas aeruginosa in feces exacerbate leaky gut in mice with low dose dextran sulfate solution, impacts of specific bacteria.
PLoS One
November 2024
Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
The impact of Pseudomonas aeruginosa (PA) was explored in a mouse model with non-diarrheal gut permeability defect using 1.5% dextran sulfate solution (DSS) plus antibiotics (ATB) with or without orally administered PA. As such, ATB+DSS+PA mice induced more severe intestinal injury as indicated by stool consistency and leaky gut (FITC-dextran assay, bacteremia, and endotoxemia) with an increase in serum cytokines, liver enzyme, and hepatocyte apoptosis when compared with ATB+DSS mice.
View Article and Find Full Text PDFSPATEs promote the survival of to the plasma complement system upon local hemorrhage and bacteremia.
Proc Natl Acad Sci U S A
November 2024
Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire (IBMC), Architecture et Réactivité de l'ARN, Strasbourg 67000, France.
spp. are the causative agents of shigellosis, which remains a leading cause of death in children under the age of 5. Symptoms of shigellosis include bloody diarrhea, associated to colon hemorrhage; in more severe cases bacteremia is induced.
View Article and Find Full Text PDFVisceral adiposity in postmenopausal women is associated with a pro-inflammatory gut microbiome and immunogenic metabolic endotoxemia.
Microbiome
October 2024
Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Article Synopsis
- * The study involved 50 postmenopausal women, divided into low and high visceral adiposity tissue (VAT) groups, assessing dietary intake, plasma endotoxemia markers, and gut microbiome through various tests.
- * Results indicated that women with high VAT had a higher abundance of Proteobacteria, increased LBP levels, and elevated LPS-expressing bacteria, suggesting a link between gut bacteria, inflammation, and obesity.
A Case of Co-infection Due to Shigella flexneri Colitis Resulting in Bacillus Septic Shock in an Immunocompetent Patient.
Cureus
July 2024
Internal Medicine, University of California, Los Angeles (UCLA) - Kern Medical, Bakersfield, USA.
Shigella flexneri (S. flexneri) is a facultatively anaerobic gram-negative bacterium that is a member of Enterobacteriaceae. The bacterium has been known to cause mild symptoms, such as diarrhea, to more severe diseases such as hemorrhagic colitis.
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