Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1089/rej.2010.1035 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Citrulline regulates macrophage metabolism and inflammation to counter aging in mice.
Sci Adv
March 2025
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China.
Metabolic dysregulation and altered metabolite concentrations are widely recognized as key characteristics of aging. Comprehensive exploration of endogenous metabolites that drive aging remains insufficient. Here, we conducted an untargeted metabolomics analysis of aging mice, revealing citrulline as a consistently down-regulated metabolite associated with aging.
View Article and Find Full Text PDFN-tert-Butylhydroxylamine promotes melanin production in oxidative stress conditions through the MITF signaling pathway.
Arch Dermatol Res
February 2025
Department of Applied Chemistry, Dong-Eui University, Busan, 47340, Republic of Korea.
During the aging process, melanogenesis is downregulated, leading to hair graying. Various agents, including α-melanocyte-stimulating hormone (α-MSH), have been evaluated for their potential to enhance melanogenesis. Among them, N-tert-Butylhydroxylamine (NtBHA) has been reported to reverse cellular aging, enhance mitochondrial function, and exhibit antioxidant properties.
View Article and Find Full Text PDFDiscovering the Potential of Cannabidiol for Cosmeceutical Development at the Cellular Level.
Pharmaceuticals (Basel)
February 2025
Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
Cannabidiol (CBD) has been used for the development of extensive cosmeceutical commercial products. However, the safety and unclear bioactivity of CBD are still concerns and need to be examined to assess the impact of CBD on skin cells through cosmeceutical applications, particularly its impact on anti-aging and wound healing activities. In our study, the cytotoxicity of CBD was investigated on keratinocytes and fibroblasts in short-term and long-term treatments using a sulforhodamine B (SRB) assay and a clonogenic assay, respectively.
View Article and Find Full Text PDFNatural Polyamine Spermidine Inhibits the In Vitro Oxidation of LDL.
Molecules
February 2025
Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria.
Spermidine is a natural autophagy-inducer and anti-aging compound. Herein, we investigated a potential autophagy-independent mechanism of spermidine, namely its capability to directly impede LDL oxidation, an early step in atherogenesis. In our in vitro-model, LDL oxidation was induced by the addition of CuCl in the presence of increasing concentrations of spermidine, and the degree of oxidation of the lipid, as well as of the protein part of LDL, was measured.
View Article and Find Full Text PDFA multiparametric anti-aging CRISPR screen uncovers a role for BAF in protein synthesis regulation.
Nat Commun
February 2025
Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Keith Peters Building, Hills Road, Cambridge, UK.
Progeria syndromes are very rare, incurable premature aging conditions recapitulating most aging features. Here, we report a whole genome, multiparametric CRISPR screen, identifying 43 genes that can rescue multiple cellular phenotypes associated with progeria. We implement the screen in fibroblasts from Néstor-Guillermo Progeria Syndrome male patients, carrying a homozygous A12T mutation in BAF.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!