AI Article Synopsis

  • Influenza A(H1N1)v emerged as a global pandemic in 2009, though it was generally mild in severity.
  • Important evolutionary changes that enabled the virus to effectively infect humans happened quickly, even before the end of April 2009.
  • Among the various clades that developed, clade 7 later dominated and replaced earlier strains prior to the majority of worldwide cases.

Article Abstract

Influenza A( H1N1)v has spread rapidly in all parts of the globe in 2009 as a true pandemic, although fortunately a clinically mild one. The relevant evolutionary steps for the new virus to adapt to human populations occurred very early during the pandemic, before the end of April. Of the several resulting clades or clusters, clade 7 appeared later and proved more successful, substituting all other early clades before the bulk of the worldwide infections occurred.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832123PMC
http://dx.doi.org/10.1371/currents.rrn1149DOI Listing

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