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[Development of Methods for the Early Detection of Chemical Hazard and the Prevention of Pre-disease, Focusing on Environment, Food, and Health].
Yakugaku Zasshi
March 2025
Graduate School of Pharmaceutical Sciences, Yokohama University of Pharmacy.
Based on the perspectives of the environment, food, and health, this review reflects on previous research examining stem cells for the early detection of chemical hazards and the development of preventive health tools. The risks posed by endocrine-disrupting chemicals in the environment are investigated, including studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), phthalate esters, and bisphenol A. Building on the findings of these studies, this review identifies emerging challenges in the field of endocrine-disrupting chemical research.
View Article and Find Full Text PDFEpigenetics-Based Age Acceleration Associated with 2,3,7,8 TCDD Exposure in Older Americans.
Int J Mol Sci
February 2025
Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul 05368, Republic of Korea.
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is highly toxic with potential impacts on aging. While previous studies have linked TCDD exposure to reduced telomere length and altered sperm DNA methylation (DNAm) age, its relationship with epigenetic aging remains unclear. This study investigated the association between serum TCDD levels and epigenetic clocks derived from DNAm in whole blood in older adults.
View Article and Find Full Text PDFUnveiling the transcriptional pattern of epithelial ovarian carcinoma-related microRNAs-mRNAs network after mouse exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin.
Reprod Toxicol
March 2025
Department of Molecular Biology and Biotechnology, Atomic Energy Commission of Syria (AECS), Damascus, Syria. Electronic address:
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), the most potent organic environmental contaminant known to date, is recognized as a human carcinogen. Despite the documented link between TCDD exposure and epithelial ovarian cancer (EOC) in mammalian females, the molecular mechanisms underlying cancer initiation remain elusive. Emerging evidence suggests aberrant miRNA expression in various human malignancies, including OC.
View Article and Find Full Text PDFAccelerated solvent extraction of dioxins sequestered in activated carbon: A response surface methodology-based optimization.
Chemosphere
March 2025
Department of Plant, Soil, and Microbial Sciences, Michigan State University, East Lansing, MI, USA. Electronic address:
Activated carbon (AC) is an effective sorbent for sequestering dioxin-like compounds, thereby reducing their bioavailability. Consequently, AC amendment is a promising tool for remediating dioxin-polluted soils, but tracking remediation results requires quantification of the dioxins sequestered within ACs. Standard methods for quantifying dioxins in soils are often unable to extract dioxins from AC, so the present study addresses this gap by optimizing an accelerated solvent extraction (ASE) method.
View Article and Find Full Text PDFDioxins and Related Compounds in Sediment and Soil from Craft Villages and Industrial Areas in Northern Vietnam.
Bull Environ Contam Toxicol
February 2025
Center for High Technology Research and Development, Vietnam Academy of Science and Technology, A28 Building, No.18 Hoang Quoc Viet Road, Cau Giay Dist., Hanoi, Vietnam.
This study focuses on the determination of dioxins and related compounds (DRCs) in sediment and soil samples gathered from craft villages and industrial zones in Bac Ninh province, northern Vietnam. The PCDD/Fs and DL-PCBs levels in sediment samples ranged from 8.34 to 1302 pg/g and 34.
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