Persistently elevated CKMB and negative troponin T in a patient at ischaemic risk with chest pain.

Cardiovasc J Afr

Department of Chemical Pathology, Universitas National Health Laboratory Services, University of the Free State, Bloemfontein, South Africa.

Published: April 2010

Analytical interference in laboratory assays is not only unpredictable but also an underestimated problem. Not recognising these interferences can lead to misdiagnosis and mismanagement of patients. We present a case of a patient with chest pain and ischaemic risk factors with incongruent biochemical results. These results were discovered to be due to the presence of macro-creatine kinase (macro-CK) in vivo interfering with the CKMB activity assay.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565915PMC

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