Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/ja.2010.15 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Molecular mechanism for the unusual enhancement of the second-step chemiluminescence production from the carcinogenic tetrabromohydroquinone and HO.
J Environ Sci (China)
July 2024
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; College of Environment and Resources, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
We have found recently that two-step intrinsic hydroxyl radical (OH)-dependent chemiluminescence (CL) could be produced by carcinogenic tetrahaloquinone and HO. However, the first-step CL was too fast to clearly detect the stepwise generation of OH and CL, and to distinguish the exact dividing point between the first-step and second-step CL. Here we found that, extremely clear two-step intrinsic CL could be produced by the relative slow reaction of tetrabromohydroquinone (TBHQ) with HO, which was directly dependent on the two-step OH generation.
View Article and Find Full Text PDFMechanistic Study on Oxidative DNA Damage and Modifications by Haloquinoid Carcinogenic Intermediates and Disinfection Byproducts.
Chem Res Toxicol
July 2021
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, P.R. China.
Article Synopsis
- Haloquinones (XQs) are identified as carcinogenic compounds derived from environmental pollutants and disinfection byproducts in drinking water.
- The study reveals that XQs can cause oxidative damage to DNA through mechanisms involving hydroxyl radicals and quinone enoxy/ketoxy radicals, independent of metal ions.
- Research shows that exposure to XQs leads to DNA modifications and breaks, potentially increasing mutagenic effects in living cells and highlighting the genotoxic risks associated with these compounds.
Disinfection byproducts potentially responsible for the association between chlorinated drinking water and bladder cancer: A review.
Water Res
October 2019
Department of Civil and Environmental Engineering, University of Surrey, Guildford, GU2 7XH, UK. Electronic address:
Epidemiological studies have consistently associated the consumption of chlorinated drinking water with an enhanced risk of bladder cancer. While this suggests that some disinfection byproducts (DBPs) are bladder carcinogens, causal agents are unknown. This study aims to highlight likely candidates.
View Article and Find Full Text PDFPotential carcinogenic hazards of non-regulated disinfection by-products: haloquinones, halo-cyclopentene and cyclohexene derivatives, N-halamines, halonitriles, and heterocyclic amines.
Toxicology
August 2011
MoBull Consulting, 1928 Meadows Drive North, Richland, WA 99352, USA.
Drinking water disinfectants react with natural organic material (NOM) present in source waters used for drinking water to produce a wide variety of by-products. Several hundred disinfections by-products (DBPs) have been identified, but none have been identified with sufficient carcinogenic potency to account for the cancer risks projected from epidemiological studies. In a search for DBPs that might fill this risk gap, the present study projected reactions of chlorine and chloramine that could occur with substructures present in NOM to produce novel by-products.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!