AI Article Synopsis
- Novel bendazac analogs and their salts were created, resulting in compounds with high solubility in water (over 100 mg/mL).
- In vitro tests indicated that many of these compounds effectively protect against oxidative damage.
- Specifically, compound 13d not only provided protection but also boosted antioxidant levels in a model of oxidative stress, suggesting it may guard the lens through antioxidant mechanisms.
Article Abstract
Novel bendazac analogues and their salts have been designed and prepared. The resulting compounds (13c-d, 15c, 17c) showed very good aqueous solubility (>100 mg/mL). An in vitro assay showed that most of the resulting compounds had potent protective activity against the oxidative damage. Particularly, compound 13d was also able to enhance the WSP and T-AOC level in the H(2)O(2)/FeCl(3)-induced oxidative damage model, indicating the resulting compound may protect the lens through an antioxidant pathway.
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| http://dx.doi.org/10.1016/j.bmcl.2010.02.061 | DOI Listing |
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