AI Article Synopsis
- The NOD2 gene is linked to a higher risk of developing Crohn's disease, which in turn increases cancer susceptibility in affected individuals.
- A study involving over 4,500 participants in Poland found significant associations between the 3020insC allele of the NOD2 gene and several cancer types, including colon, lung, ovarian, and early-onset laryngeal cancers.
- It is estimated that individuals carrying the 3020insC allele have a 30% increased lifetime risk of cancer compared to those with the typical alleles.
Article Abstract
The NOD2 gene has been associated with susceptibility to Crohn's disease and individuals with Crohn's disease are at increased risk for cancer at a number of organ sites. We studied the association between the 3020insC allele of the NOD2 gene and cancer among 2604 cancer patients and 1910 controls from Poland. Patients were diagnosed with one of twelve types of cancer in the Szczecin region between 1994 and 2004. Significant associations were found for colon cancer (OR = 1.8; 95% CI 1.2 to 2.6), for lung cancer (OR = 1.7; 95% CI = 1.1 to 2.5) and for ovarian cancer (OR = 1.6; 95% CI 1.1 to 2.3). In addition, a significant association was found for early-onset laryngeal cancer (OR = 2.9; 95% CI 1.4 to 6.2) and for breast cancer in the presence of DCIS (OR = 2.1 95% CI = 1.2 to 3.6). The NOD2 3020insC allele is relatively common (in Poland 7.3% of individuals) and may be responsible for an important fraction of cancer cases. We estimate that the lifetime cancer risk among carriers of this allele is 30% higher than that of individuals with two wild-type alleles.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837299 | PMC |
| http://dx.doi.org/10.1186/1897-4287-3-2-59 | DOI Listing |
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