A new jacaranone derivative, 2-(1,6-dihydroxy-4-oxocyclohex-2-enyl) acetic acid (1), has been isolated from the whole plants of Senecio scandens var. incisus, together with three known compounds: 2'-(p-hydroxyl-cinnamoyl)-6'-jacaranone-D-glucopyranoside (2), 2'-caffeoyl-6'-jacaranone-D-glucopyranoside (3) and kampferol-3-rhamnoside (4). Their structures were elucidated on the basis of spectroscopic data analyses and by comparison with the related known compounds. Cytotoxic activities of 1 against three human tumour cell lines have been evaluated by the MTT method.
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http://dx.doi.org/10.1080/14786410903250936 | DOI Listing |
Int J Mol Sci
December 2024
School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China.
Jacaranone derived from , a traditional Chinese medicine used for centuries, has been documented to exhibit anti-inflammatory and antiproliferative properties in various tumor cell lines. However, the mechanism of action and relationship between inflammation and apoptosis induced by jacaranone remain inadequately elucidated. In this study, the targets of jacaranone and cancer were identified from various databases, while potential targets and pathways were predicted through the analysis of the protein-protein interactions (PPI) network and pathway enrichment.
View Article and Find Full Text PDFPlants (Basel)
March 2022
Department of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary.
Jacaranones are a small group of specific plant metabolites with promising biological activities. The occurrence of jacaranones is limited to only a few plant families, with Asteraceae being the most abundant source of these compounds. Therefore, jacaranones can also serve as chemotaxonomic markers.
View Article and Find Full Text PDFMolecules
November 2018
Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Schubertstrasse 1, 8010 Graz, Austria.
The cytotoxic and antiprotozoal activities of the phytoquinoide, jacaranone, and related compounds have been an ongoing topic in recent drug discovery. Starting from the natural product-derived cyclohexadienone scaffold, a series of nitrogen-containing derivatives were synthesized and subsequently evaluated for their antiproliferative and antiprotozoal activity. Anticancer potency was analyzed using different types of cancer cell lines: MDA-MB-231 breast cancer, CCRF-CEM leukemia, HCT-116 colon cancer, U251 glioblastoma, and, in addition, non-tumorigenic MRC-5 lung fibroblasts.
View Article and Find Full Text PDFNat Prod Res
August 2019
d Département de Chimie, VARENBIOMOL, Faculté des Sciences Exactes , Université de Constantine 1, Constantine , Algérie.
Alkaloids and phenolic compounds are among the most biologically active natural products from the / genera (Asteraceae). To isolate original natural products directly from crude polar extracts, centrifugal partition chromatography (CPC) was used. Previously, we reported the phytochemical study of (syn.
View Article and Find Full Text PDFMed Chem
July 2017
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Xian Nong Tan Street, Beijing, 100050, China.
Background: The development of antiangiogenic agents arises as a more effective and selective therapeutic approach for the treatment of cancer. In addition to reduced acute toxicity, the efficacy of chemotherapy could be improved when administered in combination specific antiangiogenic with cytotoxic agents. The conjugation or hybridization of bifunctional molecules is one of the alternative rational design strategies for co-administration of anticancer drugs.
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