Diaminopyridine dendritic scaffolds encapsulate polymeric flavin via non-covalent interactions and demonstrate isolation of the redox moiety.
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Institut de recherches cliniques de Montréal, Montréal, Québec, Canada.
Unlabelled: SARS-CoV-2 infection induces interferon (IFN) response by plasmacytoid dendritic cells (pDCs), but the underlying mechanisms are poorly defined. Here, we show that the bulk of the IFN-I release comes from pDC sensing of infected cells and not cell-free virions. Physical contact (or conjugates) between pDCs and infected cells is mediated through CD54-CD11a engagement, and such conjugate formation is required for efficient IFN-I production.
View Article and Find Full Text PDFThe molecular features of non-peptidic nucleophilic substrates and acceptor proteins determine the efficiency of sortagging.
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Enamine Ltd 78 Winston Churchill Street Kyiv 02094 Ukraine +380 67 656-4026 https://www.enamine.net.
Sortase A-mediated ligation (SML) or "sortagging" has become a popular technology to selectively introduce structurally diverse protein modifications. Despite the great progress in the optimization of the reaction conditions and design of miscellaneous C- or N-terminal protein modification strategies, the reported yields of conjugates are highly variable. In this study, we have systematically investigated C-terminal protein sortagging efficiency using a combination of several rationally selected and modified acceptor proteins and a panel of incoming surrogate non-peptidic amine nucleophile substrates varying in the structural features of their amino linker parts and cargo molecules.
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Shanghai University, Shanghai, China.
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USDA-ARS, Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA. Electronic address:
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