The Sleep Heart Health Study (SHHS) is a comprehensive landmark study of sleep and its impacts on health outcomes. A primary metric of the SHHS is the in-home polysomnogram, which includes two electroencephalographic (EEG) channels for each subject, at two visits. The volume and importance of this data presents enormous challenges for analysis. To address these challenges, we introduce multilevel functional principal component analysis (MFPCA), a novel statistical methodology designed to extract core intra- and inter-subject geometric components of multilevel functional data. Though motivated by the SHHS, the proposed methodology is generally applicable, with potential relevance to many modern scientific studies of hierarchical or longitudinal functional outcomes. Notably, using MFPCA, we identify and quantify associations between EEG activity during sleep and adverse cardiovascular outcomes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835171 | PMC |
| http://dx.doi.org/10.1214/08-AOAS206SUPP | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Primary care functional features and their health impact on patients enrolled in the Shanghai family doctor service: a mixed-methods study.
J Glob Health
January 2025
China Center for Health Development Studies, Peking University, Beijing, China.
Background: While research in multiple countries confirms that primary care functional features significantly improve patient health, China's primary care system differs markedly due to unique structural and contextual factors. This study aims to measure and explore the functional features experienced by patients received family doctor contract service in the past year, evaluating the impacts and pathways of these primary care features on health outcomes.
Methods: We employed a mixed-methods explanatory sequential design.
MicroRNA-155 Inhibition Activates Wnt/β-catenin Signaling to Restore Th17/Treg Balance and Protect against Acute Ischemic Stroke.
eNeuro
January 2025
Department of Neurology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou 362002, China.
Acute ischemic stroke (AIS) is a dangerous neurological disease associated with an imbalance in Th17/Treg cells and abnormal activation of the Wnt/β-catenin signaling pathway. This study aims to investigate whether inhibition of miR-155 can activate the Wnt/β-catenin signaling pathway to improve Th17/Treg imbalance and provide neuroprotective effects against stroke. We employed a multi-level experimental design.
View Article and Find Full Text PDFDoes habit strength moderate affective responses to movement-related behaviors among older adults?
Appl Psychol Health Well Being
February 2025
Department of Kinesiology, University of North Carolina Greensboro, USA.
Physical activity (PA) and sedentary behavior (SB) are associated with affective feeling states in older adults, though the strength and direction of associations vary. This study used the Ecological Momentary Assessment (EMA) to determine how habit strength affects affective responses to movement behaviors. Older adults completed a 4-day EMA protocol with 10 randomly delivered, smartphone assessments per day while simultaneously wearing two activity monitors recording PA and SB.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
Background: Characterizing changes in cognitive function during the last years of life is vital for providing appropriate care, supporting quality of life, and planning for future demands on our medical and social resources. The aim of this project was to construct a cognitive function trajectory file spanning the last five years of life to better understand common patterns of cognitive aging.
Method: The analytic cohort included 2019 Medicare decedents, aged 50 or older at death, with five years of continuous enrollment before death (n = 1,952,408).
Background: Cardiovascular disease (CVD) increases the risk of cognitive impairment (CI), particularly in women. Physical activity and cognitive training can improve cognition, with potential interactive effects. The purpose of this study was to evaluate the efficacy of MindMoves, a 24-week multidomain physical activity and cognitive training intervention, on cognition in older women with CVD.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!