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http://dx.doi.org/10.5688/aj7308s05 | DOI Listing |
J Med Chem
January 2025
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
The tedious synthesis and limited throughput biological evaluation remain a great challenge for discovering new proteolysis targeting chimera (PROTAC). To rapidly identify potential PROTAC lead compounds, we report a platform named Auto-RapTAC. Based on the modular characteristic of the PROTAC molecule, a streamlined workflow that integrates lab automation with "click chemistry" joint building-block libraries was constructed.
View Article and Find Full Text PDFBMC Med Educ
January 2025
School of Nursing, Xiangnan University, 889 Chenzhou Avenue, Suxian District, Chenzhou, 423000, Hunan, People's Republic of China.
Background: In the backdrop of the ongoing global digital revolution in education, the digital literacy of teachers stands out as a pivotal determinant within the educational milieu. This study aims to explore the current status and associated factors of digital literacy among academic nurse educators.
Methods: A cross-sectional design study utilizing an online questionnaire platform (Wenjuanxing) to collect data from August to October 2023.
Sci Rep
January 2025
Department of Computer Science, Sapienza University of Rome, Rome, Italy.
As virality has become increasingly central in shaping information sources' strategies, it raises concerns about its consequences for society, particularly when referring to the impact of viral news on the public discourse. Nonetheless, there has been little consideration of whether these viral events genuinely boost the attention received by the source. To address this gap, we analyze content timelines from over 1000 European news outlets from 2018 to 2023 on Facebook and YouTube, employing a Bayesian structural time series model to evaluate the impact of viral posts.
View Article and Find Full Text PDFJ Environ Manage
January 2025
School of Mathematics and Statistics, University of Sydney, Sydney, NSW, Australia.
This research chooses Pakistan as an ideal case to explore the connection between economic expansion and carbon emissions, by incorporating a novel approach of using coupled stochastic equations to estimate this dynamic interaction.The GDP (Gross domestic product) in Pakistan has been ascending over the time of 1960-2023, with short episodes of stagnation (mid 80s) and decline (1973, 2009). Since 2010, the growth rate has been rising annually, reaching 4.
View Article and Find Full Text PDFJ Environ Manage
January 2025
Centro Studi PLINIVS, University of Naples Federico II, 80134, Naples, Italy; Department of Architecture, University of Naples Federico II, 80134, Naples, Italy. Electronic address:
Cities worldwide have established plans and policies to achieve climate-neutral and climate-resilient objectives in recent decades. Researches have demonstrated that Climate Change Action Plans generally fail to include mitigation and adaptation approaches in their planning processes, despite their importance. A proposed multilevel assessment of Climate Change Action Plans, urban regeneration, and building projects was used to analyze the ten cities most sustainable in terms of developing environmental strategies, including local climate action to determine the degree of adaptation and mitigation integration in cutting-edge contexts and to identify measures that show synergies and co-benefits for urban design practices.
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