We have achieved high-precision laser beam shaping by using a binary-amplitude spatial light modulator, a digital micromirror device (DMD), followed by an imaging telescope that contains a pinhole low-pass filter (LPF). An error diffusion algorithm was used to design the initial DMD pixel pattern based on the measured input beam profile. This pattern was iteratively refined by simulating the optically low-pass filtered DMD image and changing DMD pixels to lift valleys and suppress peaks. We noted the gap between the experimental result of 1.4% root-mean-square (RMS) error and the simulated result for the same DMD pattern of 0.3% RMS error. Therefore, we deemed it necessary to introduce iterative refinement based on actual measurements of the output image to further improve the uniformity of the beam. Using this method, we have demonstrated the ability to shape raw, non-spatially filtered laser beams (quasi-Gaussian beams) into beams with precisely controlled profiles that have an unprecedented level of RMS error with respect to the target profile. We have shown that our iterative refinement process is able to improve the light intensity uniformity to around 1% RMS error in a raw camera image for both 633 and 1064 nm laser beams. The use of a digital LPF on the camera image is justified in that it matches the performance of the pinhole filter in the experimental setup. The digital low-pass filtered results reveal that the actual optical beam profiles have RMS error down to 0.23%. Our approach has also demonstrated the ability to produce a range of target profiles as long as they have similar spatial-frequency content (i.e., a slowly varying beam profile). Circular and square cross-section flat-top beams and beams with a linear intensity variation within a circular and square cross section were produced with similarly low RMS errors. The measured errors were about twice the ultimate limit of 0.1% RMS error based on the number of binary DMD pixels that participate in the beam-formation process.
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http://dx.doi.org/10.1364/AO.49.001323 | DOI Listing |
Sensors (Basel)
December 2024
Institute of Mechatronics and Information Systems, Lodz University of Technology, 90-537 Lodz, Poland.
This paper is devoted to the development of a window-type inductive current transformer (iCT) with a rated primary current equal to 400 A and two secondary windings with rated currents of 5 A and 1 A. Its novelty concerns the presentation of this process in the case of an iCT with a 0.2S accuracy class ensured not only for a sinusoidal current of a frequency of 50 Hz but also for the transformation of distorted current in the harmonic frequency range from 50 Hz to 5 kHz.
View Article and Find Full Text PDFNat Commun
January 2025
Division of Gastroenterology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Single-cell RNA sequencing (scRNA-seq) has advanced our understanding of cell types and their heterogeneity within the human liver, but the spatial organization at single-cell resolution has not yet been described. Here we apply multiplexed error robust fluorescent in situ hybridization (MERFISH) to map the zonal distribution of hepatocytes, spatially resolve subsets of macrophage and mesenchymal populations, and investigate the relationship between hepatocyte ploidy and gene expression within the healthy human liver. Integrating spatial information from MERFISH with the more complete transcriptome produced by single-nucleus RNA sequencing (snRNA-seq), also reveals zonally enriched receptor-ligand interactions.
View Article and Find Full Text PDFBMC Oral Health
December 2024
Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, China.
Background: This study aims to evaluate the impact of different thresholds and voxel sizes on the accuracy of Cone-beam computed tomography (CBCT) tooth reconstruction and to assess the accuracy of fused CBCT and intraoral scanning (IOS) tooth models using curvature continuity algorithms under varying thresholds and voxel conditions.
Methods: Thirty-two isolated teeth were digitized using IOS and CBCT at two voxel sizes and five threshold settings. Crown-root fusion was performed using a curvature continuity algorithm.
J Otol
July 2024
Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Chinese PLA Medical School, Beijing, 100853, China.
Purpose: To analyze the effect of right versus left long-term single-sided deafness (SSD) on sound source localization (SSL), discuss the necessity of intervention and treatment for SSD patients, and analyze the therapeutic effect of long-term unilateral cochlear implantation (UCI) from the perspective of SSL.
Methods: This study included 25 patients with SSD, 11 patients with UCI, and 30 participants with normal hearing (NH). Their SSL ability was tested by obtaining their average root mean square (RMS) error values of SSL test.
Int J Pediatr Otorhinolaryngol
December 2024
Division of Otology, Department of Otorhinolaryngology & Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; School of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:
Introduction: Despite the reported auditory deficits and developmental challenges in children with unilateral microtia and aural atresia (UMAA), there remains a lack of consensus on early intervention with bone conduction hearing aids (BCHAs) to restore binaural hearing due to the uncertain clinical benefits and intolerability of the conventional devices. Previous studies investigating the auditory benefits under binaural hearing condition were limited and demonstrated controversial opinions in heterogenous patient groups with various devices. Our study aimed to evaluate the audiological performance, including monoaural and binaural hearing, and subjective satisfaction of the ADHEAR system, a novel adhesive BCHA, in experienced pediatric users with UMAA.
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