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The relationship between mitochondrial health, telomerase activity and longitudinal telomere attrition, considering the role of chronic stress.
Sci Rep
December 2024
Department of Psychiatry and Behavioral Sciences and Weill Center for Neurosciences, University of California, San Francisco, CA, 94107, USA.
Telomere attrition is a hallmark of biological aging, contributing to cellular replicative senescence. However, few studies have examined the determinants of telomere attrition in vivo in humans. Mitochondrial Health Index (MHI), a composite marker integrating mitochondrial energy-transformation capacity and content, may be one important mediator of telomere attrition, as it could impact telomerase activity, a direct regulator of telomere maintenance.
View Article and Find Full Text PDFA harmonized river-ocean coupled database for the northern Gulf of Mexico.
Sci Data
December 2024
Department of Mathematics, Texas A&M University, College Station, TX, 77843, USA.
The northern Gulf of Mexico (nGoM) receives water from over 50 rivers which are highly influenced by humans and include the largest river in the United States, the Mississippi River. To support large-scale data-driven research centered on the dynamic river-ocean system in the region, this study consolidated hydrogeochemical river and ocean data from across the nGoM. In particular, we harmonized 35 chemical solute parameters from 54 rivers and incorporated river discharge data to derive daily solute concentration and flux estimates throughout the nGoM.
View Article and Find Full Text PDFDetermining effective dietary and ruminal fermentation parameters on live weight gain in diets formulated with selected agro-industrial by-products and their validation in performance fattening lambs.
Transl Anim Sci
December 2024
Department of International Development, School of Agriculture, Policy and Development, University of Reading, Reading RG6 6EU, UK.
The objective of this study was to determine the effects of dietary agro-industrial by-products (AIBP) with different amounts of metabolizable energy (ME) and crude protein (CP) on fermentation (96 h) and gas production (GP) kinetics in vitro, as well as acceptability, animal performance, digestibility, and blood parameters in lambs. The gas production technique (GPT) and fermentation characteristics were used in an in vitro trial. This experiment used diets with ME contents of 6.
View Article and Find Full Text PDFAssessment and management of frailty in individuals living with dementia: expert recommendations for clinical practice.
Lancet Healthy Longev
December 2024
Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway; Centre for Healthy Brain Ageing, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Frailty complicates the care of individuals with dementia, increasing their vulnerability to adverse outcomes. This Personal View presents expert recommendations for managing frailty in individuals with dementia, aimed at health-care providers, particularly those in primary care. We conducted a rapid literature review followed by a consensus process involving 18 international experts on dementia and frailty.
View Article and Find Full Text PDFCombined Use of Intranasal Methylprednisolone and Allopregnanolone: Revisiting Anti-inflammatory and Remyelinating Treatment in a Murine Model of Multiple Sclerosis.
Front Biosci (Landmark Ed)
December 2024
Department of Immunology, Institute of Biomedical Research Universidad Nacional Autónoma de México, UNAM, 04510 Mexico City, Mexico.
Background: Multiple sclerosis (MS) is a demyelinating, neuroinflammatory, progressive disease that severely affects human health of young adults. Neuroinflammation (NI) and demyelination, as well as their interactions, are key therapeutic targets to halt or slow disease progression. Potent steroidal anti-inflammatory drugs such as methylprednisolone (MP) and remyelinating neurosteroids such as allopregnanolone (ALLO) could be co-administered intranasally to enhance their efficacy by providing direct access to the central nervous system (CNS).
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