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Clinical outcomes of atrial fibrillation screening: a meta-analysis of randomized controlled trials.
Ann Med
December 2025
Heart Centre, Turku University Hospital, Turku, Finland.
Background: Several randomized controlled trials (RCTs) have investigated the benefits of atrial fibrillation (AF) screening. However, since none have shown a significant reduction in stroke rates, the impact of screening on clinical outcomes remains uncertain.
Materials And Methods: We conducted a systematic review and meta-analysis of RCTs reporting clinical outcomes of systematic AF screening in participants without known AF.
Time series segmentation for recognition of epileptiform patterns recorded via microelectrode arrays in vitro.
PLoS One
January 2025
Instituto de Microelectrónica de Sevilla (IMSE-CNM), Consejo Superior de Investigaciones Científicas (CSIC) and Universidad de Sevilla, Sevilla, Spain.
Epilepsy is a prevalent neurological disorder that affects approximately 1% of the global population. Approximately 30-40% of patients respond poorly to antiepileptic medications, leading to a significant negative impact on their quality of life. Closed-loop deep brain stimulation (DBS) is a promising treatment for individuals who do not respond to medical therapy.
View Article and Find Full Text PDFAssociation of extreme heat events with sleep and cardiovascular health: a scoping review.
Syst Rev
January 2025
Weill Cornell Medicine, Department of Medicine, 525 E 68th St, New York, NY, 10065, USA.
Background: Extreme heat events (EHEs), driven by anthropogenic climate change, exacerbate the risk of cardiovascular disease (CVD), although the underlying mechanisms are unclear. A possible mechanism leading to heat-related CVD is disturbances in sleep health, which can increase the risk of hypertension, and is associated with ideal cardiovascular health. Thus, our objective was to systematically review the peer-reviewed literature that describes the relationship between EHEs, sleep health, and cardiovascular measures and outcomes and narratively describe methodologies, evidence, and gaps in this area in order to develop a future research agenda linking sleep health, EHEs, and CVD.
View Article and Find Full Text PDFFast vocal-motor tracking of escaping prey in echolocating bats.
BMC Biol
January 2025
Department of Biology, Section of Zoophysiology, Aarhus University, Aarhus, 8000, Denmark.
Background: Echolocating bats face an intense arms race with insect prey that can detect bat calls and initiate evasive maneuvers. Their high closing speeds and short biosonar ranges leave bats with only a few 100 ms between detection and capture, suggesting a reactive sensory-motor operation that might preclude tracking of escaping prey. Here we test this hypothesis using greater mouse-eared bats (Myotis myotis) as a model species.
View Article and Find Full Text PDFTimely access to specialist outpatient care: can applying systems thinking unblock our waiting lists?
BMC Health Serv Res
January 2025
Centre for the Business and Economics of Health (CBEH), The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
Background: The purpose of this qualitative study was to focus on review and repeat review outpatients and the structural role they play in exacerbating waitlists for Specialist Outpatient (SOP) services in Queensland. Waitlists, which record the number of patients waiting for an initial consultation (new appointment), are an indicator of a health system under strain. Waiting too long to access SOP can have a detrimental effect on people's health outcomes.
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