Background: In recent years, laparoscopic equipment, and experience with its use, has improved. We are now able to appreciate microanatomy, and dissection of individual lymphatic channels is possible. Previously, the results of laparoscopic lymphatic-sparing procedures has been reported. In this study, we report our experience of the preservation of both the lymphatic channels and the testicular artery during laparoscopic varicocelectomy and its outcomes.
Materials And Methods: All boys undergoing laparoscopic varicocelectomy between June 2004 and February 2009 were included in the study. The demographic details, operative findings, complications, and length of stay were recorded on a Microsoft Excel spreadsheet and complications at follow-up noted. The operation was performed via a transperitoneal approach, and the retroperitoneum was entered proximal to the internal ring by peritoneal division over the vessels. The spermatic vein or veins were isolated and stripped of the surrounding lymphatics and artery and secured with ligaclips. Any other tortuous veins around the internal ring were also ligated at the time of operation.
Results: Nineteen boys underwent laparoscopic varicolectomy. Complications were 1 intraoperative small bowel injury, 1 hydrocele (5%), and 4 persistent varices (21%), one of which was symptomatic, requiring a low ligation of spermatic veins through a groin approach.
Conclusions: This study shows good results with regard to postoperative hydrocoele rates. The preservation of the lymphatic supply ensures adequate lymphatic drainage, therefore, minimizing the risk of developing a hydrocele postoperatively. The risk of persistent varices, compared to the traditional en-masse technique, is a source of concern and requires further study.
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http://dx.doi.org/10.1089/lap.2009.0186 | DOI Listing |
Nat Commun
January 2025
Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Alzheimer's disease is characterized by progressive amyloid deposition and cognitive decline, yet the pathological mechanisms and treatments remain elusive. Here we report the therapeutic potential of low-intensity 40 hertz blue light exposure in a 5xFAD mouse model of Alzheimer's disease. Our findings reveal that light treatment prevents memory decline in 4-month-old 5xFAD mice and motivation loss in 14-month-old 5xFAD mice, accompanied by restoration of glial water channel aquaporin-4 polarity, improved brain drainage efficiency, and a reduction in hippocampal lipid accumulation.
View Article and Find Full Text PDFDev Cell
December 2024
Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:
Lymphatic muscle cells (LMCs) within the wall of collecting lymphatic vessels exhibit tonic and autonomous phasic contractions, which drive active lymph transport to maintain tissue-fluid homeostasis and support immune surveillance. Damage to LMCs disrupts lymphatic function and is related to various diseases. Despite their importance, knowledge of the gene transcriptional signatures in LMCs and how they relate to lymphatic function in normal and disease contexts is largely missing.
View Article and Find Full Text PDFEur Arch Otorhinolaryngol
December 2024
ENT Department, Sydney Adventist Hospital, Sydney, NSW, Australia.
Background: Meniere's disease (MD) is a disabling disease of the inner ear, having a substantial effect on a patient's quality of life. While various postulations regarding its aetiology exists, due to the difficulty with accessing inner ear tissue, there have been limited histological studies in patients with active MD.
Methods: Tissue was collected during labyrinthectomy from 8 patients with intractable MD who had failed medical therapy (22 samples), and 9 patients undergoing translabyrinthine resection of vestibular schwannoma (19 samples).
Urol Case Rep
January 2025
Mayo Clinic Department of Interventional Radiology, 200 1st St SW, Rochester, MN 55905, USA.
Management of symptomatic lymphoceles typically involves sclerotherapy and lymphangiography with embolization. When many afferent lymphatic channels are supplying a large-volume lymphocele, sclerotherapy is associated with high recurrence rate. This case presents a patient who underwent retroperitoneal lymph node dissection and developed a high-volume lymphocele that was compressing the ipsilateral ureter, causing hydronephrosis.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
November 2024
Center for Evidence-based Chinese Medicine, Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700, China.
Life is a dynamic and systematic whole, with organs interacting with each other. Traditional Chinese medicine(TCM) discusses the interaction between human tissue and organs through the Zangfu relations, while modern biological medicine clarifies physiological and pathological relationships through "organ crosstalk". From the perspective of "organ crosstalk", this article discussed the five classical Zangfu relations(lungs and large intestine, heart and small intestine, spleen and stomach, liver and gallbladder, and kidney and bladder) in TCM and their extension.
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