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CK19 protein expression: the best cutoff value on the prognosis and the prognosis model of hepatocellular carcinoma.
BMC Cancer
January 2025
Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi Province, 530021, China.
Background And Objective: In clinical practice, CK19 can be an important predictor for the prognosis of HCC. Due to the high incidence and mortality rates of HCC, more effective and practical prognostic prediction models need to be developed urgently.
Methods: A total of 1,168 HCC patients, who underwent radical surgery at the Guangxi Medical University Cancer Hospital, between January 2014 and July 2019, were recruited, and their clinicopathological data were collected.
New FDA drug approvals for 2024: Synthesis and clinical application.
Eur J Med Chem
January 2025
Department of Plastic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China. Electronic address:
In 2024, the U.S. Food and Drug Administration (FDA) has approved a range of new drugs, including both 32 new chemical entities (NCEs) and 18 biological entities (NBEs).
View Article and Find Full Text PDFA comprehensive analysis of the impact of arsenic, fluoride, and nitrate-nitrite dynamics on groundwater quality and its health implications.
J Hazard Mater
January 2025
Third World Center (TWC) for Science and Technology, H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address:
Groundwater contamination is a growing global concern. The objective of the present study is to assess the groundwater quality of Khairpur district, Sindh, Pakistan-a region which is emblematic of broad environmental and public health challenges prevalent in South Asian countries. The study also aims to comprehend the impact of arsenic (As), fluoride (F), and nitrate (NO) dynamics and its health implications.
View Article and Find Full Text PDFCultivating cultural empathy among diabetes educators: A pre-post evaluation of a digital story intervention.
Contemp Nurse
January 2025
Faculty of Health, University of Technology Sydney, 235 Jones Street, Ultimo, NSW 2007, Australia.
Indigenous Australians are disproportionately affected by diabetes, with a diagnosis rate nearly four times higher than people from a non-Indigenous background. This health disparity highlights the urgent need for healthcare providers to develop cultural empathy - a critical competency for delivering culturally safe and person-centered care. Cultural empathy is essential for building trust and effective communication in diabetes education and management within Indigenous people.
View Article and Find Full Text PDFBackground: The emergence of new biomarkers for Alzheimer's disease is accompanied by the urgent need to evaluate their diagnostic performance in comparison to existing technologies. Meta-analysis methods make best use of the available evidence by synthesizing all relevant published studies. Meta-analytic models that estimate comparative diagnostic accuracy are key to informing healthcare decision-making around which tests should be used in clinical practice.
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