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Novel PD-L1/VISTA Dual Inhibitor as Potential Immunotherapy Agents.
J Med Chem
December 2024
State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
Inhibiting the activity of immune checkpoint proteins to reignite the antitumor activity of immune cells has emerged as a pivotal strategy. PD-L1 and VISTA, as critical proteins governing immune regulation, are concurrently upregulated under conditions such as hypoxia. Through a rational drug design process, , a dual-target inhibitor for PD-L1 and VISTA is identified.
View Article and Find Full Text PDFNovel insights into high-order dispersion and soliton dynamics in optical fibers via the perturbed Schrödinger-Hirota equation.
Sci Rep
December 2024
College of Computer Science, Chengdu University, Chengdu, 610106, China.
This study offers a comprehensive analysis of the Perturbed Schrödinger -Hirota Equation (PSHE), crucial for understanding soliton dynamics in modern optical communication systems. We extended the traditional Nonlinear Schrödinger Equation (NLSE) to include higher-order nonlinearities and spatiotemporal dispersion, capturing the complexities of light pulse propagation. Employing the modified auxiliary equation method and Adomian Decomposition Method (ADM), we derived a spectrum of exact traveling wave solutions, encompassing exponential, rational, trigonometric, and hyperbolic functions.
View Article and Find Full Text PDFA novel conformable fractional-order accumulation grey model and its applications in forecasting energy consumption of China.
Sci Rep
December 2024
School of Mathematical Sciences, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Accurate forecasting of energy consumption demand is crucial to optimize resources and achieve sustainable development goals. However, the energy system is affected by many factors, which are complex and highly uncertain. Therefore, a novel grey model (IBCFGMP (1,1,N)) is proposed, integrating multiple optimization techniques such as background value optimization, initial condition optimization, fractional-order accumulation optimization, and grey action quantity optimization.
View Article and Find Full Text PDFSimultaneous Detection of Multiple Analytes at Ambient Temperature Using Eukaryotic Artificial Cells with Modular and Robust Synthetic Riboswitches.
ACS Synth Biol
December 2024
Proteo-Science Center, Ehime University, 2-5 Bunkyo, Matsuyama, Ehime 790-8577, Japan.
Cell-free systems, which can express an easily detectable output (protein) with a DNA or mRNA template, are promising as foundations of biosensors devoid of cellular constraints. Moreover, by encasing them in membranes such as natural cells to create artificial cells, these systems can avoid the adverse effects of environmental inhibitory molecules. However, the bacterial systems generally used for this purpose do not function well at ambient temperatures.
View Article and Find Full Text PDFThe Interfacial Interpenetration Effect for Controlled Reaction Stability of Palladium Catalysts.
J Am Chem Soc
December 2024
Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
Tailoring well-defined interfacial structures of heterogeneous metal catalysts has become an effective strategy for identifying the interface relationships and facilitating the reactions involving multiple intermediates. Here, a particle-particle heterostructure catalyst consisting of Pd and copper oxide nanoparticles is designed to achieve high-performance alkaline methanol oxidation electrocatalysis. The strong coupling particle-particle heterostructure catalyst induced a unique interfacial interpenetration effect to improve the interfacial charge redistribution and regulate the -band structure for optimizing the adsorption of CO intermediates on the catalyst.
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