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The immunological bases of alemtuzumab as induction-therapy in pediatric-onset multiple sclerosis.
Front Immunol
January 2025
Department of Neurosciences, University of Padua, Padua, Italy.
Pediatric-Onset Multiple Sclerosis (POMS) is characterized by both white and grey matter inflammation, as well as by a higher risk of long-term physical and cognitive disability. The peculiar immunopathogenic mechanisms of POMS suggests that the use of induction therapies, including alemtuzumab (ALTZ), might be a promising approach, at least for postpuberal (> 11 yo) POMS. Although no data on the use of induction therapies in POMS are available from clinical trials currently, case series or case reports on the effect of alemtuzumab (ALTZ) have been recently published.
View Article and Find Full Text PDFLeveraging human centered design to enhance clinician communication during pregnancy care: Overcoming language barriers with Spanish-speaking patients.
PEC Innov
June 2025
Ariadne Labs at Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, 401 Park Dr, 3rd Floor, Boston, MA 02215, USA.
Background: Engaging patients in quality improvement and innovation projects is increasingly important, yet challenges persist with involving patients who speak languages other than English. This article presents design activities our team used to engage Spanish-speaking patients and cultural brokers.
Objective: To develop a clinician communication tool to enhance patient trust in pregnancy care clinicians, especially among minoritized populations who face language and cultural barriers, using human-centered design (HCD).
Nanoparticles in gynecologic cancers: a bibliometric and visualization analysis.
Front Oncol
January 2025
Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Background: Gynecological cancers are characterized by uncontrolled cell proliferation within the female reproductive organs. These cancers pose a significant threat to women's health, impacting life expectancy, quality of life, and fertility. Nanoparticles, with their small size, large surface area, and high permeability, have become a key focus in targeted cancer therapy.
View Article and Find Full Text PDFChanges in health related quality of life in mothers with inflammatory joint disease from year 2000 to 2020 - a comparative cross-sectional study.
Front Glob Womens Health
January 2025
Department of Research, Nord-Trøndelag Hospital Trust, Levanger, Norway.
Objectives: More knowledge about health related quality of life (HRQoL) among mothers with inflammatory joint disease (IJD) is needed to understand the complex challenges for this group of patients. The overall aim of this study was to investigate changes in HRQoL among mothers with IJD from year 2000 to year 2020.
Methods: This study had a comparative cross-sectional design with two study groups 20 years apart, year 2000 ( = 77) and year 2020 ( = 197).
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