A 42-year-old woman was admitted to our hospital because of an abnormal shadow on chest X-ray. Chest computed tomography scan revealed a tumor 4.0 cm in diameter in the right segment S8. We resected the right lower lobe because of the possibility of lung cancer. Historical finding of the resected specimen revealed epithelial-myoepithelial carcinoma of the lung. The patient has remained disease-free for a year and 3 months postoperatively.
Adenomyoepithelioma (AME) is a rare variant of breast neoplasm. It is a biphasic tumour characterized by small epithelial-lined spaces with inner luminal cells and outer of abluminal (myoepithelial) cells. Either - or both - of these two cells may rarely undergo malignant transformation.
Objective: The clinical characteristics and prognosis of primary epithelial-myoepithelial carcinoma of salivary gland (EMC-SG) have not been defined well due to its rarity. The purpose of this study is to assess the proportion of EMC-SG among salivary gland cancers, describe the clinicopathological features and prognosis of this disease, further analyze the factors associated with EMC-SG survival, and establish individual survival-predicting models.
Methods: Data on patients diagnosed with salivary gland malignancy between 2000 and 2020 were collected from the Surveillance, Epidemiology, and End Results database.
Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan 2nd Road, Guangzhou, 510080, China.
The study discusses challenges in classifying salivary gland malignancies due to their similar features, highlighting the usefulness of molecular phenotyping, particularly through next-generation sequencing (NGS).
A case of a young female with a salivary gland tumor at the tongue base was presented, revealing an EWSR1::BEND2 gene fusion through RNA-based NGS, which is a rare finding in this type of cancer.
The findings suggest that the EWSR1::BEND2 fusion may play a significant role in the development of salivary gland tumors, indicating that RNA-based NGS is crucial for accurate diagnosis and understanding of this rare malignancy.
Epithelial-myoepithelial carcinoma (EMC) is a rare low-grade malignant tumor with uncommon regional lymph node metastasis and distant metastasis. The diagnosis of this disease primarily relies on the examination of pathological morphology and immunohistochemical staining, as its clinical symptoms and imaging findings are non-specific. This makes it more difficult to provide specific information about EMC lung metastasis.
- Hybrid carcinomas (HC) in salivary glands are rare tumors that involve the combination of two or more malignant neoplasms, primarily occurring in the parotid gland and often in male patients.
- The study reviewed 18 articles with data on 34 patients, finding that adenoid cystic carcinoma and epithelial-myoepithelial carcinoma were the most common types, and surgical excision followed by radiotherapy was the typical treatment approach.
- There’s a need for further research to understand whether HC are distinct from individual cancer types, as the most aggressive tumor component should determine treatment strategies to improve patient outcomes.
