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Mapping Thrombosis Serum Markers by H-NMR Allied with Machine Learning Tools.
Molecules
December 2024
Laboratory of Hemostasis, Hemocentro-Unicamp, Universidade Estadual de Campinas, Campinas 13083-878, SP, Brazil.
Machine learning and artificial intelligence tools were used to investigate the discriminatory potential of blood serum metabolites for thromboembolism and antiphospholipid syndrome (APS). H-NMR-based metabonomics data of the serum samples of patients with arterial or venous thromboembolism (VTE) without APS (n = 32), thrombotic primary APS patients (APS, n = 32), and healthy controls (HCs) (n = 32) were investigated. Unique metabolic profiles between VTE and HCs, APS and HCs, and between VTE and triple-positive APS groups were indicative of the significant alterations in the metabolic pathways of glycolysis, the TCA cycle, lipid metabolism, and branched-chain amino acid (BCAA) metabolism, and pointed to the complex pathogenesis mechanisms of APS and VTE.
View Article and Find Full Text PDFCerebral venous thrombosis as a rare complication of Sjögren's syndrome: case series and literature review.
Clin Rheumatol
January 2025
Department of Rheumatology & Allergy, Xuanwu Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- This study examines a rare complication of cerebral venous thrombosis (CVT) in patients with primary Sjögren's syndrome (pSS), discussing clinical features, treatment, and outcomes.
- A total of twelve patients were reviewed, predominantly middle-aged women, with common symptoms including headache and typical pSS manifestations such as dry mouth and arthritis.
- All patients received treatment including anticoagulants and recovered fully, highlighting the need for increased awareness and screening for autoimmune diseases in CVT cases, especially with unilateral transverse sinus involvement.
Bullous Pyoderma Gangrenosum Associated with Antiphospholipid Syndrome: A Case Report and Literature Review.
Oman Med J
July 2024
Family Medicine General Foundation Program, Oman Medical Specialty Board, Muscat, Oman.
We report a rare case of a middle-aged Omani woman who was known to have primary antiphospholipid syndrome, glucose-6-phosphate dehydrogenase deficiency, and iron deficiency anaemia. Cannulation attempts caused bulla which progressed to ulceration. A pathergy phenomenon with high suspicion of pyoderma gangrenosum was postulated.
View Article and Find Full Text PDF[Use of hydroxychloroquine in recurrent immune-mediated obstetric diseases (excluding systemic lupus): Scientific basis and evidence].
Rev Med Interne
December 2024
Service de médecine interne et inflammation, département inflammation-immunopathologie-biothérapie (DMU I3), CEREMAIAA, hôpital Saint-Antoine, AP-HP, Sorbonne université, Paris, France.
Hydroxychloroquine (HCQ), a synthetic antimalarial, is recognized for its immunomodulatory, anti-inflammatory and vascular-protective effects. In 20-30% of cases of primary obstetrical antiphospholipid syndrome (APS), the combination of antiplatelet aggregation and prophylactic anticoagulation fails to prevent obstetrical complications, a situation referred to as refractory obstetrical APS. This is partly due to the pro-inflammatory effects of antiphospholipid antibodies (aPL) binding to decidual and trophoblastic cells, which compromise embryonic implantation and placentation.
View Article and Find Full Text PDFPreceding Antiphospholipid Syndrome before the Onset of Systemic Lupus Erythematosus Presenting with Iliocaval Deep Vein Thrombosis: A Case Report and Literature Review.
Ann Vasc Dis
December 2024
Department of Vascular Surgery, Tokoname Municipal Hospital, Tokoname, Aichi, Japan.
Antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) are similar to be characterized by thromboembolic events and various clinical manifestations. We experienced a 21-year-old man with acute iliocaval deep vein thrombosis (DVT). Primary APS was initially diagnosed on the criteria, and after multidisciplinary treatment, iliocaval DVT was gradually regressed.
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