AI Article Synopsis

  • The study investigates the effects of combining enteral nutrition (EN) with parenteral nutrition (PN) on glucose control in stressed patients, particularly those undergoing oesophagectomy for adenocarcinoma.
  • Results show that the combination of EN and PN leads to lower glucose levels and reduced insulin resistance compared to PN alone.
  • Additionally, this combination improves intestinal integrity and increases levels of the incretin hormone GIP, suggesting a better overall metabolic response.

Article Abstract

The provision of parenteral nutrition (PN) to 'stressed' patients often results in hyperglycaemia, which may be detrimental. In animal models limited amounts of enteral nutrition (EN) improve intestinal integrity and stimulate intestinal incretin production, which may lead to improved glucose control. We set out to assess if combining EN with PN results in improved glucose homeostasis rather than PN given alone. We conducted a randomised trial in a university teaching hospital of patients undergoing a 'curative' oesophagectomy for adenocarcinoma. Differences between the two intervention groups were assessed for continuous glucose measurement, insulin sensitivity using insulin tolerance tests (ITT) and homeostasis model analysis (HOMA), the incretin glucose-dependent insulinotropic polypeptide (GIP) and intestinal permeability. The combination of PN with EN resulted in lower interstitial glucose concentrations (P = 0.002), reduced insulin resistance, improved insulin sensitivity (HOMA-insulin resistance (IR) P = 0.045; HOMA beta P = 0.037; ITT P = 0.006), improved intestinal permeability (P < 0.001) and increased GIP (P = 0.01) when compared with PN alone. The combination of EN with PN, when compared with PN alone, results in reduced glucose concentrations, reduced insulin resistance, increased incretins and improvements in intestinal permeability.

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http://dx.doi.org/10.1017/S0007114509993631DOI Listing

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