AI Article Synopsis
- The study reports on the KIR gene distribution in 205 healthy mestizo Venezuelans, marking the first analysis of its kind.
- All KIR genes were present, with inhibitory KIRs having high frequencies (over 0.69), except for KIR2DL2 (0.29) and KIR2DL5 (0.37).
- A total of 45 KIR genotypes were identified, with three predominant ones found in over half of the individuals; 25.9% were homozygous for haplotype A, indicating the impact of ethnic admixture in this population.
Article Abstract
This study represents the first report on the distribution of KIR genes in 205 unrelated healthy mestizo Venezuelan individuals. Genotyping analysis showed that all KIR genes are present in this population. Frequency of inhibitory killer cell immunoglobulin-like receptors (KIRs) exceeded 0.69, except for KIR2DL2 (0.29) and 2DL5 (0.37). Activating KIRs showed low frequencies (0.11-0.29), except for KIR2DS4 (0.68). Forty-five different KIR genotypes were identified, with a predominance of three genotypes found in 50.7% of the population of which 25.9% were individuals homozygous for haplotype A. The frequencies of KIR genes reflect the ethnic admixture existing in the mestizo Venezuelan population.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366394 | PMC |
| http://dx.doi.org/10.1111/j.1399-0039.2010.01446.x | DOI Listing |
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