First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816990 | PMC |
| http://dx.doi.org/10.1117/1.3285504 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Elevated Frame Rates During Exercise Echocardiography Improve Speckle Tracking Success Rate and Augment Deformation Values.
Am J Physiol Heart Circ Physiol
January 2025
COR-HELIX, Institute of Sport Science, Leibniz University Hannover, Hannover, Germany.
Although 2D speckle-tracking echocardiography (STE) is important for the clinical quantification of myocardial function it remains unknown whether increased frame rates during exercise STE augment tracking success and absolute deformation values. 19 participants (15 male and 4 female; age 26.7±4.
View Article and Find Full Text PDFA key contribution to X-ray dark-field (XDF) contrast is the diffusion of X-rays by sample structures smaller than the imaging system's spatial resolution; this is related to position-dependent small-angle X-ray scattering. However, some experimental XDF techniques have reported that XDF contrast is also generated by resolvable sample edges. Speckle-based X-ray imaging (SBXI) extracts the XDF by analyzing sample-imposed changes to a reference speckle pattern's visibility.
View Article and Find Full Text PDFProgrammable scanning diffuse speckle contrast imaging of cerebral blood flow.
Neurophotonics
January 2025
University of Kentucky, Department of Biomedical Engineering, Lexington, Kentucky, United States.
Significance: Cerebral blood flow (CBF) imaging is crucial for diagnosing cerebrovascular diseases. However, existing large neuroimaging techniques with high cost, low sampling rate, and poor mobility make them unsuitable for continuous and longitudinal CBF monitoring at the bedside.
Aim: We aimed to develop a low-cost, portable, programmable scanning diffuse speckle contrast imaging (PS-DSCI) technology for fast, high-density, and depth-sensitive imaging of CBF in rodents.
State-dependent neurovascular modulation induced by transcranial ultrasound stimulation.
Med Biol Eng Comput
January 2025
School of Biomedical Engineering, Shanghai Jiao Tong University, No.1954 Huashan Road, Shanghai, 200030, Shanghai, China.
Previous studies reported baseline state-dependent effects on neural and hemodynamic responses to transcranial ultrasound stimulation. However, due to neurovascular coupling, neither neural nor hemodynamic baseline alone can fully explain the ultrasound-induced responses. In this study, using a general linear model, we aimed to investigate the roles of both neural and hemodynamic baseline status as well as their interactions in ultrasound-induced responses.
View Article and Find Full Text PDFSpeckle-illumination spatial frequency domain imaging with a stereo laparoscope for profile-corrected optical property mapping.
J Biomed Opt
January 2025
The Johns Hopkins University, Department of Biomedical Engineering, Baltimore, Maryland, United States.
Significance: Laparoscopic surgery presents challenges in localizing oncological margins due to poor contrast between healthy and malignant tissues. Optical properties can uniquely identify various tissue types and disease states with high sensitivity and specificity, making it a promising tool for surgical guidance. Although spatial frequency domain imaging (SFDI) effectively measures quantitative optical properties, its deployment in laparoscopy is challenging due to the constrained imaging environment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!