[Bioactive constituents from whole herbs of Vernonia cinerea (II)].

Objective: To study the constituents of the whole herbs of Vernonia cinerea by bio-activity guided isolation with PC-12 model.

Method: The constituents were separated by column chromatography and the structures were elucidated by spectroscopic methods.

Result: Ten compounds were identified to be (-)-clovane-2,9-diol (1), caryolane-1,9beta-diol (2), apigenin (3), chrysoeriol (4), luteolin (5), thermopsoside (6), luteolin-7-O-beta-D-glucoside (7), quercetin(8), apigenin-4'-O-beta-D-glucoside (9), hyperin (10), beta-amyrin aceate (11), lupeol acetate (12).

Conclusion: Compounds 1, 2, 6 and 10 were isolated from this genus for the first time.