AI Article Synopsis
- The study aimed to investigate the relationship between serum total IgE levels and eosinophil counts with the effectiveness of medication in patients experiencing acute asthma.
- A total of 162 patients were evaluated by measuring their IgE levels, blood cell counts, and lung function before and after a two-week treatment period.
- The results showed no significant differences in treatment responses based on IgE levels, indicating that these factors do not predict how well patients will respond to asthma medication.
Article Abstract
Objective: To determine whether serum total IgE levels and total eosinophil counts have any relationship with the response to routine pharmacological treatment in patients with acute asthma.
Methods: A cross-sectional study involving 162 patients with acute asthma. Serum total IgE levels, peripheral blood cell counts and eosinophil counts were determined. The treatment was adjusted for each patient according to the severity of asthma. Spirometry was performed at baseline and two weeks after the treatment. The patients were divided into two groups: high IgE (>100 IU/mL) and low IgE (<100 IU/mL). We compared the two groups in terms of the relationships between baseline values and final values (percentage change) for the following parameters: FEV1, FVC, FEF25-75%, peripheral white blood cell counts and eosinophil counts.
Results: There were no significant differences between the groups regarding the percentage changes of the studied parameters. Nor were there significant differences between the groups regarding FEV1, FVC, and FEF25-75% (% of the predicted values) at baseline.
Conclusions: On the basis of these findings, we conclude that serum total IgE levels, peripheral white blood cell counts and eosinophil counts cannot predict the response to the pharmacological treatment of patients with acute asthma.
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| http://dx.doi.org/10.1590/s1806-37132010000100006 | DOI Listing |
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