We report the design, synthesis and properties of spiroindane based compound 1, a potent, selective, orally bioavailable, non-peptide melanocortin subtype-4 receptor agonist. Compound 1 shows excellent erectogenic activity in the rodent models.
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| http://dx.doi.org/10.1016/j.bmcl.2010.02.058 | DOI Listing |
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