AI Article Synopsis
- The study explored the relationship between gene variation in the follicle stimulating hormone receptor (FSHR) and superovulation response in Chinese Holstein cows.
- It discovered a significant single nucleotide polymorphism (SNP), G-278A, where cows with the CC genotype showed higher total numbers of ova and transferable embryos compared to those with other genotypes (CD and DD).
- The findings suggest that the FSHR gene could serve as a valuable predictor for superovulation outcomes in this breed of cows.
Article Abstract
To identify a predictor to forecast superovulation response on the basis of associations between superovulation performance and gene polymorphism, variation in the bovine follicle stimulating hormone receptor (FSHR) gene was investigated using PCR-single-strand conformational (PCR-SSCP) and DNA sequencing. One single nucleotide polymorphism (SNP) of G-278A located in the 5' upstream region of bovine FSHR gene was found in 118 Chinese Holstein cows treated for superovulation. Two SNPs of G-278A (GU253337) and A-320T (rs43676359) were analyzed. In polymorphic locus -278, all cows without superovulation response were mutations with genotypes of CD and DD. Cows with CC genotype had a significant increase in the total number of ova (TNO) (P<0.01), and produced more transferable embryos (NTE) than those of the CD and DD genotypes (P<0.01). At this locus, the additive effects seemed to be highly significant (P<0.01) and allele C was associated with an increase in the TNO and NTE. These results indicated that the FSHR is a potential marker for superovulation response and can be used as a predictor for superovulation in Chinese Holstein cows.
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| http://dx.doi.org/10.1016/j.anireprosci.2010.02.004 | DOI Listing |
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