AI Article Synopsis
- Antibiotic "tolerance" is a rare phenomenon where bacteria can survive at higher concentrations of antibiotics than what is normally considered effective.
- Although tests based on minimal inhibitory concentration (MIC) may show that these bacteria are susceptible, they can still thrive at bactericidal concentrations that are not achievable in human serum.
- A unique case of persistent methicillin-sensitive S. aureus (MSSA) bacteremia was reported, involving a linezolid-tolerant strain that did not respond to daptomycin treatment, marking a significant finding in antibiotic resistance research.
Article Abstract
Antibiotic "tolerance" is a rare cause of antibiotic failure. Antibiotic "tolerance" is defined as an minimal bactericidal concentration (MBC) 32x the minimal inhibitory concentration (MIC) of the isolate. Although susceptibility testing based on the MIC suggests susceptibility of "tolerant" strains, bactericidal concentrations are often beyond achievable serum levels and therapeutic failure may result. We present a case of persistent methicillin-sensitive S. aureus (MSSA) bacteremia due to a linezolid "tolerant" strain unresponsive to daptomycin therapy. We believe this is the first report of persistent MSSA bacteremia due to a linezolid "tolerant" strain.
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| http://dx.doi.org/10.1016/j.hrtlng.2009.06.005 | DOI Listing |
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