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Prognostic and predictive implications of sterile alpha motif and HD domain-containing protein 1 (SAMHD1) expression in breast cancer.
Int J Cancer
December 2024
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a dNTP hydrolase important for intracellular dNTP homeostasis and serves as tumor suppressor and modulator of antimetabolite efficacy in cancer, though largely unexplored in breast cancer (BC). A cohort of patients with early BC (n = 564) with available gene expression data (GEP) was used. SAMHD1 protein expression was assessed by immunohistochemistry performed on tissue microarrays.
View Article and Find Full Text PDFDental Practitioners' Knowledge and Attitudes Toward the Etiology, Diagnosis, and Treatment of Peri-Implantitis.
Dent J (Basel)
November 2024
Department of Preventive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
The objective of this study was to assess the level of knowledge and attitude about the etiology, diagnosis, and management of peri-implantitis among dental practitioners. An online cross-sectional study on 303 dentists in Saudi Arabia was conducted. A closed-ended survey consisting of 28 questions was designed.
View Article and Find Full Text PDFPrognostic significance of blood immune cells in children with sepsis and establishment of a predictive model for PICU mortality: a retrospective study.
Front Pediatr
December 2024
Department of Pediatric Intensive Care Unit, First Affiliated Hospital of Guangxi Medical University, Guangxi, China.
Objectives: This article aimed to investigate the correlation between blood immune cells and the prognosis in the early phase of pediatric sepsis and construct a prediction model for pediatric intensive care unit (PICU) mortality.
Methods: A total of 348 children admitted with sepsis to our PICU were retrospectively collected between January 2020 and June 2024. Of these, 242 children admitted from January 2020 to October 2022 were designated as the modeling group, while 106 children admitted between November 2022 and June 2024 were designated as the prospective validation group.
Neuroendocrine tumors (NETs) of the biliary tract are extremely rare due to a paucity of Kulchitsky cells. While their preoperative diagnosis remains challenging due to the lack of specific diagnostic markers and imaging findings, there have been no detailed reports describing the diagnostic utility of various imaging modalities for bile duct NETs at the junction of the cystic and common hepatic ducts. We report a case of a woman in her 40s who presented with jaundice and elevated hepatobiliary enzymes.
View Article and Find Full Text PDFPreventative treatment of tuberous sclerosis complex with sirolimus: Phase I safety and efficacy results.
Ann Child Neurol Soc
June 2024
Division of Neurology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Objective: Tuberous sclerosis complex (TSC) results from overactivity of the mechanistic target of rapamycin (mTOR). Sirolimus and everolimus are mTOR inhibitors that treat most facets of TSC but are understudied in infants. We sought to understand the safety and potential efficacy of preventative sirolimus in infants with TSC.
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