AI Article Synopsis
- A 54-year-old immunocompetent German patient was diagnosed with primary varicella (chickenpox) and showed early T-cell responses to the Varicella-Zoster Virus (VZV) before developing antibodies.
- The case highlights the importance of detecting VZV-specific T-cells as a diagnostic tool for primary varicella, especially in atypical or mild cases.
- This method can be particularly useful when VZV DNA is not detectable in the patient's plasma.
Article Abstract
Here we report the case of a 54-year old, immunocompetent German patient with primary varicella whose Varicella-Zoster Virus (VZV)-specific T-cell responses could be detected early in infection and before the onset of seroconversion. This case demonstrates that the detection of VZV-specific T-cells may under certain circumstances support the diagnosis of a primary varicella infection, as for example in cases of atypical or subclinical varicella or in the absence of detectable VZV DNA in plasma.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839977 | PMC |
| http://dx.doi.org/10.1186/1743-422X-7-54 | DOI Listing |
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