AI Article Synopsis
- The one-pot Horner-Wadsworth-Emmons/oxa-Michael cascade is a chemical reaction process used to synthesize complex molecules.
- This method produces the tetracyclic benzannulated spiroketal core of berkelic acid, which is a natural product derived from extremophiles (organisms that thrive in extreme conditions).
- Berkelic acid has shown selective activity against ovarian cancer, indicating potential as a therapeutic compound.
Article Abstract
The one-pot Horner-Wadsworth-Emmons/oxa-Michael cascade followed by spiroketalisation affords the tetracyclic benzannulated spiroketal core of berkelic acid, an extremophile natural product with selective activity against ovarian cancer.
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| http://dx.doi.org/10.1039/b927219b | DOI Listing |
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