AI Article Synopsis
- The study evaluated mortality risk factors in older patients with bloodstream infections at a French geriatric unit, involving 167 individuals split into two age groups (60-85 years and ≥85 years).
- Key findings revealed that low albumin levels, high C-reactive protein (CRP), and moderate fever were significant risk factors for 60-day mortality, with a mortality rate of 32.3%.
- The research concluded that age alone is not a mortality risk factor for bloodstream infections, but highlights the need for tailored management strategies for the elderly in such cases.
Article Abstract
The purpose of this retrospective study was to evaluate risk factors of mortality in bloodstream infections in old and very old people in a French geriatric unit (Paul Brousse Hospital, APHP). 167 older patients with bloodstream infections were included and two groups were compared according to age (60-85 years and ≥85 years). Information was collected for each patient: age, sex, diseases, urinary catheter, temperature, signs of severe sepsis, biological examinations, bacteria and antibiotic treatments. All bacteremias were nosocomial. There was no difference between groups for pathogen, source or prognosis. Mortality rate at 60 days was 32.3%. The risk factors for mortality were: low albumin rate (p<0.001), high C-reactive protein (CRP) (p=0.02) and moderate fever (p=0.006). Multivariate logistic regression showed that these three parameters were significantly associated with a risk of mortality. The parameter with the highest risk was a low albumin rate <30 g/l. Malnutrition may be a more long-term risk factor. A moderate fever probably results in a more frequent delay in diagnosis in this population. Our work supports that age is not a risk factor of mortality for bloodstream infections. However management of bacteremia has to be adapted to elderly.
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| http://dx.doi.org/10.1016/j.archger.2010.01.012 | DOI Listing |
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