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Seroma control in axillary lymphadenectomy with Glubran 2® without drain. Multicenter, prospective, randomized, clinical trial. GALA-ND study (Glubran, Axillary Lymphadenectomy, Ambulatory, No Drain).
Trials
February 2024
General Surgeon, Breast Cancer Unit of Maresme Health Consortium (Mataró Hospital), Carr. de Cirera, 230, 08304 Mataró, Barcelona, Spain.
Background: Seroma after breast cancer surgery is a frequent entity; therefore, different products have been described in literature with the aim to reduce it. The most studied ones have been the sealants products, being tested with aspirative drains. Symptomatic seroma represents the 19% after axillary lymphadenectomy without drains.
View Article and Find Full Text PDFFibrin Sealants and Axillary Lymphatic Morbidity: A Systematic Review and Meta-Analysis of 23 Clinical Randomized Trials.
Cancers (Basel)
April 2021
Breast Surgery Unit, Department of Surgery, San Raffaele University Hospital, via Olgettina 60, 20132 Milan, Italy.
Article Synopsis
- The study investigates whether fibrin sealants can reduce complications related to axillary lymphadenectomy, similar to their effects seen in other types of lymphadenectomy.
- A total of 23 randomized trials were analyzed, encompassing patients who underwent axillary lymphadenectomy for various cancers.
- Results showed that while fibrin sealants decreased overall drainage output, duration of drainage, and hospital stay, they did not significantly impact the occurrence of lymphocele or surgical site complications.
Retrospective Evaluation of the Effectiveness of a Synthetic Glue and a Fibrin-Based Sealant for the Prevention of Seroma Following Axillary Dissection in Breast Cancer Patients.
Front Oncol
July 2020
Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy.
Seroma formation represents one of the most frequent postoperative complications of axillary dissection in breast cancer (BC) patients. We aimed to retrospectively explore the effectiveness of the intraoperative use of a synthetic cyanoacrylate glue (specifically Glubran®2) vs. the intraoperative use of a fibrin sealant (specifically Tisseel) in reducing seroma formation compared to the use of nonsealant in BC patients who underwent breast surgery and axillary dissection.
View Article and Find Full Text PDFEffects of Fibrin Sealant on Seroma Reduction for Patients with Breast Cancer Undergoing Axillary Dissection: Meta-Analysis of Randomized Controlled Trials.
Ann Surg Oncol
December 2020
Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Background: Seroma formation is common in patients with breast cancer after axillary dissection. Fibrin sealant, containing fibrinogen and thrombin, has been developed to improve wound healing. We conducted a systematic review and meta-analysis to evaluate the efficacy of fibrin sealants in reducing seroma among patients with breast cancer undergoing axillary dissection.
View Article and Find Full Text PDFReduction of postoperative lymphorrhoea in patients undergoing radical lymphadenectomy for stage III melanoma: prospective study using collagen-fibrin patches.
Minerva Chir
April 2020
Department of Dermatology, University of Florence, Florence, Italy.
Background: Radical lymph nodes dissection (RLND) is the standard procedure for regional control of disease in patients with metastatic melanoma (stage III). Because of its aggressiveness, lymphorrhoea is a constant problem in postoperative.
Methods: In this prospective nonrandomized study with a retrospective analysis of data, patients undergoing surgical treatment of axillary or iliac-inguinal RLND received standard treatment plus a collagen-fibrin sealant patch (TachoSil) (N.
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