We infected squirrel monkeys (Saimiri sciureus) with Nipah virus to determine the monkeys' suitability for use as primate models in preclinical testing of preventive and therapeutic treatments. Infection of squirrel monkeys through intravenous injection was followed by high death rates associated with acute neurologic and respiratory illness and viral RNA and antigen production.
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http://dx.doi.org/10.3201/eid1603.091346 | DOI Listing |
Herpesviruses, including the oncogenic Epstein-Barr Virus (EBV), must bypass host DNA sensing mechanisms to establish infection. The first viral latency protein expressed, EBNA-LP, is essential for transformation of naïve B cells, yet its role in evading host defenses remains unclear. Using single-cell RNA sequencing of EBNA-LP-Knockout (LPKO)-infected B cells, we reveal an antiviral response landscape implicating the 'speckled proteins' as key restriction factors countered by EBNA-LP.
View Article and Find Full Text PDFJ Zoo Wildl Med
December 2024
San Diego Zoo Wildlife Alliance, San Diego, CA 92112, USA.
Yersiniosis due to can be associated with high morbidity and mortality in various species and has been a cosmopolitan management challenge in zoological institutions. This gram-negative, environmental bacterium thrives in cold, wet conditions and poses a risk to zoo species. Outbreaks can be costly and impact conservation efforts through loss of threatened and endangered species.
View Article and Find Full Text PDFVet Pathol
December 2024
The University of Texas MD Anderson Cancer Center, Bastrop, TX.
Neoplasms are only sporadically reported in New World primates and rarely in owl monkeys (), specifically. Previous reports of neoplasms in owl monkeys are primarily restricted to lymphoma induced by infection, although other tumors in the central nervous, genitourinary, gastrointestinal, and endocrine systems have been sporadically reported. Herein, we describe 3 previously unreported neoplasms in owl monkeys () including a pericardial mesothelioma in a 6-year-old male, a nephroblastoma in a 2-year-old male, and a cervical neoplasm with characteristics of an epithelioid trophoblastic tumor in a 4-year-old female, all occurring in the same closed breeding colony at a research facility in central Texas.
View Article and Find Full Text PDFAnimals (Basel)
November 2024
Psychology, Faculty of Natural Sciences, University of Stirling, Stirling FK9 4LA, UK.
Mixed-species groups have been recorded in various primates, including tufted capuchin and squirrel monkeys. Measures of their 'groupness' are typically based on factors such as group stability, social interactions, proximity, or behavioural coordination. Social network analysis has become a useful tool for quantifying relationships among group-living individuals.
View Article and Find Full Text PDFInt J Parasitol Parasites Wildl
December 2024
Vaxinano SAS, 84 Rue Du Dr Yersin, 59120, Loos, France.
is a ubiquitous parasite causing significant mortality in captive wildlife, especially marsupials. Historically, treatment has been unrewarding and no vaccine was available. An intranasal vaccine based on purified inactivated was developed for toxoplasmosis prevention.
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