Background: Neurocysticercosis (NC) is one of the most frequent parasitic diseases of the central nervous system. Cysticidal drugs, albendazole and praziquantel, are generally effective when parasites localize in the parenchyma. In contrast, parasites lodged in the subarachnoid basal cisterns are less responsive to treatment.
Case Presentation: The clinical and radiological pictures of six Mexican patients non-respondent to cysticidal treatment are presented.
Conclusions: The possible factors involved in the cysticidal non-response are discussed and hints are provided of potentially useful changes to therapeutic protocols.
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http://dx.doi.org/10.1186/1471-2377-10-16 | DOI Listing |
Acta Parasitol
January 2025
Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Purpose: The current study aimed to investigate the trophocidal and cysticidal activities of cinnamaldehyde (Cinn), a natural compound with known antimicrobial properties, against environmental and reference strains of Acanthamoeba castellanii. Additionally, we explored the potential benefits of Cinn formulated as a nanoemulsion (Cinn-NE) in enhancing its efficacy.
Methods: Cinn-NE was prepared using the ultrasonic emulsification method.
Future Microbiol
January 2025
Department of Neurology, King George's Medical University, Lucknow, India.
Aims: Spinal neurocysticercosis is a rare central nervous system infection caused by the larval form of the . Due to its rarity, most knowledge is derived from isolated case reports. This review aims to evaluate existing case reports and observational studies to provide a comprehensive overview of the disease's clinical presentation and treatment outcomes.
View Article and Find Full Text PDFMem Inst Oswaldo Cruz
November 2024
Comenius University in Bratislava, Faculty of Natural Sciences, Department of Zoology, Bratislava, Slovakia.
Background: Acanthamoebae are causative agents of severe and complicated human infections without a standard effective therapy to date. Therefore, the research is focused on the development of new amoebicidal drugs based on the natural products. Plants of the family Lamiaceae are typical with several phenolic secondary metabolites that make them interesting in medical point of view.
View Article and Find Full Text PDFExpert Rev Anti Infect Ther
December 2024
School of Medicine and Research Center, Universidad Espíritu Santo - Ecuador, Samborondón, Ecuador.
Introduction: Calcifications are the end stage of many parenchymal brain cysticerci and may occur either spontaneously or as the result of treatment with cysticidal drugs. These lesions, traditionally considered inert and asymptomatic, have been associated with several complications that seem to be mostly related to brain damage and inflammation ensuing as the result of the exposure of the host's immune system to parasitic antigens trapped within calcifications.
Areas Covered: This review, based on the search of different electronic databases up to May 2024, focuses on the reported correlates and complications of calcified cysticerci (chronic headaches, seizures/epilepsy, hippocampal atrophy/sclerosis, gliomas), and the different interventions developed for their prevention and treatment.
Microorganisms
August 2024
Department of Parasitology and Tropical Medicine, and Institute of Health Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea.
keratitis (AK) is a sight-threatening and difficult-to-treat ocular infection. The significant side effects of current AK treatments highlight the urgent need to develop a safe and effective AK medication. In this study, the amoebicidal activity of Pall.
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